Director Shareholding

AstraZeneca PLC
21 February 2002


DEALING BY DIRECTORS

COMPANIES ACT 1985 SECTION 324/329

WE HEREBY INFORM YOU THAT, ON 19 FEBRUARY 2002, WE WERE NOTIFIED BY DR C E
WILHELMSSON, A DIRECTOR OF THE COMPANY, THAT, ON 19 FEBRUARY 2002, HE SOLD
OPTIONS OVER ASTRAZENECA PLC ORDINARY SHARES OF USD0.25 EACH AS FOLLOWS:-


NUMBER OF OPTIONS SOLD       SALE PRICE PER OPTION       DATE OF SALE

3,442                        298.80SEK                   19.02.02


3,267                        285.37SEK                   19.02.02


THESE OPTIONS WERE ORIGINALLY GRANTED TO DR WILHELMSSON OVER SHARES IN ASTRA AB
UNDER THE ASTRA SHAREHOLDER VALUE INCENTIVE PLAN AND WERE CONVERTED INTO OPTIONS
OVER ORDINARY SHARES IN ASTRAZENECA PLC IN APRIL 1999.  DETAILS OF THE
UNDERLYING ASTRAZENECA SHARES OVER WHICH THE OPTIONS WERE HELD ARE AS FOLLOWS:-


NUMBER OF ASTRAZENECA    EFFECTIVE OPTION PRICE     CLOSING PRICE OF ASTRAZENECA
SHARES OVER WHICH        PER SHARE                  SHARES ON DATE OPTIONS WERE
OPTIONS WERE HELD                                   SOLD

4,630                     298.28SEK                       518SEK

4,395                     316.13SEK                       518SEK


FOLLOWING THESE TRANSACTIONS, DR WILHELMSSON HOLDS OPTIONS OVER 100,736 ORDINARY
SHARES OF ASTRAZENECA PLC.


G H R MUSKER
COMPANY SECRETARY

21 FEBRUARY 2002



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