Director Shareholding

AstraZeneca PLC
4 December 2001



DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTIONS 324/329


ASTRAZENECA PLC ANNOUNCES THAT, ON 3 DECEMBER 2001, DR T F W MCKILLOP, A
DIRECTOR OF THE COMPANY, ACQUIRED 508 OF THE COMPANY'S USD0.25 ORDINARY SHARES
AT A PRICE OF 1357P FOLLOWING THE EXERCISE OF AN OPTION UNDER THE COMPANY'S
SAVINGS RELATED SHARE OPTION SCHEME. DR MCKILLOP'S INTEREST IN THE ORDINARY
SHARES OF THE COMPANY HAS INCREASED TO 74,443 SHARES WHICH REPRESENTS LESS
THAN 0.005 PER CENT OF THE NUMBER OF SHARES IN ISSUE. DR MCKILLOP NOW HAS
OPTIONS OVER 259,256 ORDINARY SHARES.



G H R MUSKER
COMPANY SECRETARY
4 DECEMBER 2001