Director Shareholding

AstraZeneca PLC
26 November 2002



DEALING BY DIRECTORS

COMPANIES ACT 1985 SECTION 324/329



WE HEREBY INFORM YOU THAT, ON 25 NOVEMBER 2002, WE WERE NOTIFIED BY DR H L
MOGREN, A DIRECTOR OF THE COMPANY, THAT, ON 25 NOVEMBER 2002, HE SOLD OPTIONS
OVER ASTRAZENECA PLC ORDINARY SHARES OF USD0.25 EACH AS FOLLOWS:-


NUMBER OF OPTIONS SOLD            SALE PRICE PER OPTION     DATE OF SALE


9,217                             67.59SEK                  25.11.02



THESE OPTIONS WERE ORIGINALLY GRANTED TO DR MOGREN OVER SHARES IN ASTRA AB UNDER
THE ASTRA SHAREHOLDER VALUE INCENTIVE PLAN AND WERE CONVERTED INTO OPTIONS OVER
ORDINARY SHARES IN ASTRAZENECA PLC IN APRIL 1999.  DETAILS OF THE UNDERLYING
ASTRAZENECA SHARES OVER WHICH THE OPTIONS WERE HELD ARE AS FOLLOWS:-


NUMBER OF ASTRAZENECA SHARES OVER                               CLOSING PRICE OF ASTRAZENECA
WHICH OPTIONS WERE HELD                                         SHARES ON DATE OPTIONS WERE
                                                                SOLD

                                   EFFECTIVE OPTION PRICE PER
                                   SHARE


12,400                             298.28SEK                    345SEK





FOLLOWING THESE TRANSACTIONS, DR MOGREN HOLDS OPTIONS OVER 204,425 ORDINARY
SHARES OF ASTRAZENECA PLC.



G H R MUSKER

COMPANY SECRETARY

26 NOVEMBER 2002


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