Director Shareholding

AstraZeneca PLC
29 October 2003

DEALING BY DIRECTORS

COMPANIES ACT 1985 SECTIONS 324/329



WE HEREBY INFORM YOU THAT ON 29 OCTOBER 2003 SIR TOM MCKILLOP, A DIRECTOR OF THE
COMPANY, EXERCISED OPTIONS OVER ASTRAZENECA PLC USD0.25 ORDINARY SHARES UNDER
THE COMPANY'S 1993 SENIOR STAFF SHARE OPTION SCHEME AND 1994 EXECUTIVE SHARE
OPTION SCHEME.  THE DETAILS OF THE EXERCISES ARE AS FOLLOWS:-


                             NUMBER OF SHARES OVER
                             WHICH OPTION EXERCISED
                                                    EXERCISE PRICE PER
                                                    SHARE
                                                                       PERIOD WHEN EXERCISABLE
NAME OF DIRECTOR

SIR TOM MCKILLOP              1,900                 748p               05.4.97-04.4.04

SIR TOM MCKILLOP             12,424                 826p               17.4.97-16.8.04



AS A RESULT OF THESE EXERCISES SIR TOM MCKILLOP HOLDS OPTIONS OVER 453,242
ORDINARY SHARES OF ASTRAZENECA PLC.



WE ALSO INFORM YOU THAT ON 29 OCTOBER 2003, SIR TOM MCKILLOP SOLD 5,482
ASTRAZENECA PLC USD0.25 ORDINARY SHARES AT AN AVERAGE PRICE OF 2857p PER SHARE
TO COVER THE COST OF THE EXERCISES AND TO MEET CERTAIN TAX OBLIGATIONS ARISING
FROM THE TRANSACTIONS.



FOLLOWING THESE TRANSACTIONS SIR TOM MCKILLOP HAS INCREASED HIS HOLDING IN THE
COMPANY BY 8,842 SHARES TO 78,402 SHARES WHICH REPRESENTS APPROXIMATELY 0.005
PER CENT OF THE ISSUED ORDINARY CAPITAL OF THE COMPANY.







G H R MUSKER

COMPANY SECRETARY

29 OCTOBER 2003




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