Director Shareholding

AstraZeneca PLC
20 November 2003

DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTION 324/329



WE HEREBY INFORM YOU THAT, ON 19 NOVEMBER 2003, WE WERE NOTIFIED BY DR H L
MOGREN, A DIRECTOR OF THE COMPANY, THAT, ON 19 NOVEMBER 2003, HE SOLD 6,535
OPTIONS OVER ASTRAZENECA PLC ORDINARY SHARES OF USD0.25 EACH.



THESE OPTIONS WERE ORIGINALLY GRANTED TO DR MOGREN IN 1997 OVER SHARES IN ASTRA
AB UNDER THE ASTRA SHAREHOLDER VALUE INCENTIVE PLAN.  THE OPTIONS WERE
SUBSEQUENTLY CONVERTED INTO OPTIONS OVER ORDINARY SHARES IN ASTRAZENECA PLC IN
APRIL 1999.  DETAILS OF THE UNDERLYING ASTRAZENECA SHARES OVER WHICH THE OPTIONS
WERE HELD ARE AS FOLLOWS:-


NUMBER OF ASTRAZENECA         EFFECTIVE OPTION       MARKET PRICE OF 
SHARES OVER                   PRICE PER              ASTRAZENECA SHARES WHEN
WHICH OPTIONS WERE HELD       SHARE                  OPTIONS WERE SOLD


8,792                         316.13SEK              358SEK





FOLLOWING THIS TRANSACTION, DR MOGREN HOLDS OPTIONS OVER 261,184 ORDINARY SHARES
OF ASTRAZENECA PLC.



G H R MUSKER
COMPANY SECRETARY

20 NOVEMBER 2003


                      This information is provided by RNS
            The company news service from the London Stock Exchange