Director Shareholding

AstraZeneca PLC
23 September 2004

DEALINGS BY DIRECTORS

COMPANIES ACT 1985 SECTIONS 324/329



WE HEREBY INFORM YOU THAT ON 23 SEPTEMBER 2004, MR J R SYMONDS, A DIRECTOR OF
ASTRAZENECA PLC WAS GRANTED AN OPTION UNDER THE COMPANY'S SAVINGS RELATED SHARE
OPTION PLAN.  THE OPTION IS EXERCISABLE OVER THE COMPANY'S USD0.25 ORDINARY
SHARES.




                          NUMBER OF
                          ADDITIONAL SHARES
                          UNDER OPTION        EXERCISE PRICE                             TOTAL NUMBER OF
                                              PER SHARE                                  SHARES UNDER OPTION
                                                                PERIOD WHEN EXERCISABLE

NAME OF DIRECTOR
J R SYMONDS               418                 2262P             01.12.07-31.05.08        252,855







G H R MUSKER

COMPANY SECRETARY

23 SEPTEMBER 2004


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