Director Shareholding

AstraZeneca PLC
17 January 2005


DEALING BY DIRECTORS

COMPANIES ACT 1985 SECTION 324/329


WE HEREBY INFORM YOU THAT, ON 14 JANUARY 2005, DR H L MOGREN, A DIRECTOR OF THE
COMPANY, CEASED TO HAVE AN INTEREST IN AN OPTION OVER 6,462 ASTRAZENECA PLC
ORDINARY SHARES OF USD0.25 EACH FOLLOWING ITS EXPIRY.

THE OPTION WAS ORIGINALLY GRANTED TO DR MOGREN IN 1998 FOR A PERIOD OF SEVEN
YEARS OVER SHARES IN ASTRA AB UNDER THE ASTRA SHAREHOLDER VALUE INCENTIVE PLAN.
THE OPTION WAS SUBSEQUENTLY CONVERTED INTO AN OPTION OVER ORDINARY SHARES IN
ASTRAZENECA PLC IN APRIL 1999.  THE OPTION HAS NOT BEEN EXERCISED BY DR MOGREN
AND HAS CONSEQUENTLY EXPIRED ON REACHING THE SEVENTH ANNIVERSARY OF THE DATE OF
GRANT.  DETAILS OF THE OPTION ARE AS FOLLOWS:-


NUMBER OF ASTRAZENECA SHARES OVER    EFFECTIVE OPTION PRICE PER MARKET PRICE OF ASTRAZENECA SHARES WHEN
WHICH OPTION WAS HELD                SHARE                      OPTION EXPIRED


6,462                                410.53SEK                  245.00SEK


FOLLOWING THE EXPIRY OF THIS OPTION, DR MOGREN HOLDS OPTIONS OVER 254,722
ORDINARY SHARES OF ASTRAZENECA PLC.


G H R MUSKER

COMPANY SECRETARY

17 JANUARY 2005


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