Director Shareholding

AstraZeneca PLC
01 March 2005


Dealing by Directors
Companies Act 1985 Sections 324/329


We hereby inform you that on 28 February 2005 Dr John Patterson, a Director of
the Company, purchased 150 AstraZeneca PLC USD0.25 Ordinary Shares at a price of
2093 pence per share.

Following this purchase, Dr Patterson's total holding in the Company is 503
shares, which represents approximately 0.00003% of the issued ordinary capital
of the Company.

Dr Patterson also holds options over 144,174 Ordinary Shares of AstraZeneca PLC
previously granted to him under various of the Company's share option schemes.


G H R Musker
Company Secretary
1 March 2005


                      This information is provided by RNS
            The company news service from the London Stock Exchange