Director Shareholding

AstraZeneca PLC
23 May 2005

Dealing by Directors
Companies Act 1985 Sections 324/329


We hereby inform you that, on 23 May 2005, Sir Tom McKillop, a Director of the
Company, acquired 447 of the Company's USD0.25 Ordinary Shares at a price of
£22.64 per share following the exercise of an option under the AstraZeneca
Savings-Related Share Option Scheme.


Sir Tom McKillop's interest in the Ordinary Shares of the Company has increased
to 92,615 shares, which represents approximately 0.006 per cent of the number of
shares in issue.   Sir Tom McKillop now has options over 678,611 Ordinary
Shares.


G H R Musker
Company Secretary
23 May 2005






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