Director Shareholding

AstraZeneca PLC
01 June 2005


Dealing by Directors
Companies Act 1985 Sections 324/329


We hereby inform you that options granted over the Company's USD0.25 Ordinary
Shares to the following Directors under the AstraZeneca Savings-Related Share
Option Scheme, having not been exercised during the six-month exercise period,
lapsed on 1 June 2005.


                      Number of shares
                      over which option
                      was held            Exercise price per                         Total number of
                                          share                                      shares under option
Name of                                                       Period when
Director                                                      exercisable

Sir Tom McKillop      130                 2971p               01.12.04-31.5.05       678,481

J R Symonds           195                 2971p               01.12.04-31.5.05       312,558

J S Patterson         447                 2264p               01.12.04-31.5.05       196,635


G H R Musker

Company Secretary

1 June 2005

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