Directorate Change

AstraZeneca PLC
18 February 2008

AstraZeneca PLC appoints new Non-Executive Director



AstraZeneca today announced that Jean-Philippe Courtois is to join the Board of
Directors as a Non-Executive Director with immediate effect.  Jean-Philippe
Courtois is currently President of Microsoft International, a territory that
spans 100 subsidiaries operating in over 240 countries outside the United States
and Canada, and a Senior Vice-President of Microsoft Corporation.



Louis Schweitzer, Chairman of AstraZeneca said: 'We are very pleased that
Jean-Philippe Courtois has agreed to join us.  His considerable experience in
global sales and marketing, including emerging markets, will be of great benefit
to the work of the Board'.



No disclosure obligations arise under paragraph (1) to (6) of Listing Rule
9.6.13 of the UK Listing Authority's Listing Rules in respect of the appointment
of Jean-Philippe Courtois.



18 February 2008



Media Enquiries:

Steve Brown,  [phone]  (24 hours)
Chris Sampson,  [phone]  (24 hours)
Neil McCrae,  [phone]  (24 hours)



Investor Enquiries:

Jonathan Hunt,  [phone]
Ed Seage,  [phone]
Karl Hard,  [phone]
Jorgen Winroth,  [phone]
Mina Blair,  [phone]
Peter Vozzo, (MedImmune)  [phone]



About AstraZeneca

AstraZeneca is a major international healthcare business engaged in research,
development, manufacturing and marketing of prescription pharmaceuticals and
supplier for healthcare services. AstraZeneca is one of the world's leading
pharmaceutical companies with healthcare sales of US $29.55 billion and is a
leader in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology
and infection product sales. AstraZeneca is listed in the Dow Jones
Sustainability Index (Global) as well as the FTSE4Good Index.





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