Directors' Dealings

ASTRAZENECA PLC
26 August 1999


TO COMPANY ANNOUNCEMENTS OFFICE

DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTIONS 324/329

WE HEREBY INFORM YOU THAT ON 25 AUGUST 1999 THE FOLLOWING DIRECTOR OF THE
COMPANY WAS GRANTED AN OPTION UNDER THE COMPANY'S 1994 EXECUTIVE SHARE OPTION
SCHEME.  THE OPTION IS EXERCISABLE OVER THE COMPANY'S USD0.25 ORDINARY SHARES.

NAME OF          NUMBER OF      EXERCISE     PERIOD WHEN        TOTAL NUMBER
DIRECTOR         SHARES UNDER   PRICE PER    EXERCISABLE        OF SHARES
                 OPTION         SHARE                           UNDER OPTION

J R SYMONDS      29,342         2505P        25.8.02-24.8.09    73,406


FROM G H R MUSKER
COMPANY SECRETARY