Directors' Dealings

AstraZeneca PLC
16 November 1999

TO: COMPANY ANNOUNCEMENTS OFFICE

DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTIONS 324/329

WE HEREBY INFORM YOU THAT, ON 15 NOVEMBER 1999, DR T F W MCKILLOP, A DIRECTOR
OF THE COMPANY, ACQUIRED 1,372 OF THE COMPANY'S USD0.25 ORDINARY SHARES AT A
PRICE OF 754P FOLLOWING THE EXERCISE OF AN OPTION UNDER THE COMPANY'S SAVINGS
RELATED SHARE OPTION SCHEME. DR MCKILLOP'S INTEREST IN THE ORDINARY SHARES OF
THE COMPANY HAS INCREASED TO 65,176 SHARES WHICH REPRESENTS APPROXIMATELY
0.004 PER CENT OF THE NUMBER OF SHARES IN ISSUE. DR MCKILLOP NOW HAS OPTIONS
OVER 142,684 ORDINARY SHARES.

FROM:  G H R MUSKER
       COMPANY SECRETARY