Directors' Notification of Dealing in Shares

AstraZeneca PLC
8 May 2000


DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTION 324/329

WE HEREBY INFORM YOU THAT THE FOLLOWING DIRECTORS OF THE COMPANY HAVE TODAY
SOLD ASTRAZENECA PLC ORDINARY SHARES OF USD0.25 EACH AT 2687 PENCE PER SHARE.
THE SALES WERE MADE BY THE COMPANY ON BEHALF OF THE DIRECTORS IN ORDER TO MEET
AN IMMEDIATE INCOME TAX LIABILITY ARISING ON THE RELEASE OF SHARES FROM THE
COMPANY'S EXECUTIVE SHARE RETENTION SCHEME.

                     NUMBER       TOTAL         PERCENTAGE
NAME OF              OF SHARES    INTEREST      OF ISSUED
DIRECTOR             SOLD         AFTER SALE    SHARES

SIR DAVID BARNES     4,587        209,989       0.012

T F W McKILLOP       4,669         60,507       0.003


G H R MUSKER
COMPANY SECRETARY