Directors' Notification of Dealing in Shares

AstraZeneca PLC
25 August 2000

WE HEREBY INFORM YOU THAT ON 23 AUGUST 2000 THE FOLLOWING DIRECTORS OF
ASTRAZENECA PLC WERE GRANTED OPTIONS UNDER THE ASTRAZENECA SHARE OPTION PLAN. 
THE OPTIONS ARE EXERCISABLE OVER THE COMPANY'S USD0.25 ORDINARY SHARES.


NAME OF DIRECTOR  NUMBER OF    EXERCISE PRICE  PERIOD WHEN    TOTAL  
                  SHARES UNDER PER SHARE       EXERCISABLE    NUMBER OF       
                    OPTION                                      SHARES UNDER  
                                                                  OPTION

T F W MCKILLOP    29,097         3093P       23.8.03-22.8.10  193,889
H L MOGREN        21,823         3093P       23.8.03-22.8.10  133,282         
A B T STAVLING    13,417         3093P       23.8.03-22.8.10   74,497
J R SYMONDS       28,451         3093P       23.8.03-22.8.10  102,155
C E WILHELMSSON   12,932         3093P       23.8.03-22.8.10   81,278


G H R MUSKER
COMPANY SECRETARY