Final Results - Part 1 of 2

AstraZeneca PLC 29 January 2004 AstraZeneca PLC Fourth Quarter and Full Year Results 2003 'Achievements in 2003 position AstraZeneca for strong sales and profit growth' Financial Highlights (before Exceptional Items) Group 4th Quarter 4th Quarter Actual CER Full Year Full Year Actual CER 2003 2002 % % 2003 2002 % % $m $m $m $m Sales 4,875 4,901 -1 -8 18,849 17,841 +6 - Operating Profit 849 1,074 -21 -26 4,111 4,356 -6 -11 Profit before Tax 869 1,081 -20 -25 4,202 4,387 -4 -9 Earnings per Share Before Exceptional Items $0.38 $0.45 -17 -22 $1.78 $1.84 -3 -9 Statutory (FRS3) $0.38 $0.25 +52 +42 $1.78 $1.64 +9 +3 All narrative in this section refers to growth rates at constant exchange rates (CER) • Sales for key growth and launch products increased by 45 percent to $8.2 billion and now comprise 44 percent of total company sales. • Sales for the full year were unchanged at CER whilst absorbing the loss of $2.6 billion in US sales of PrilosecTM , ZestrilTM and NolvadexTM. • Operating profit for the full year was $4,111 million, down 11 percent, on planned investments in R&D and SG&A required to effect the portfolio transformation. • NexiumTM sales were $3.3 billion for the full year, up 62 percent. • SeroquelTM sales increased by 27 percent to $1.5 billion for the full year. Approval in the US for the use of SeroquelTM in the treatment of acute bipolar mania was received 12 January 2004. • IressaTM sales reached $228 million for the full year, chiefly in the US ($102 million) and Japan ($101 million). • CrestorTM sales were $129 million for the full year. In the week ending 16 January, Crestor TM share of new prescriptions in the US statin market reached 4.6 percent. • On 23 December ExantaTM received its first regulatory approval (in France) and regulatory submissions were made in the US and European Union for key chronic indications, including prevention of stroke associated with atrial fibrillation. • Dividend increased by 13.6 percent to $0.795 for the full year. New $4 billion share repurchase programme approved, for completion by the end of 2005. Sir Tom McKillop, Chief Executive, said: 'Achievements in 2003 when sales of key growth and launch products increased by 45 percent to $8.2 billion, propel AstraZeneca into an era of strong sales and profit growth, with a financial performance likely to rank amongst the best of our peer group. For 2004 we anticipate earnings per share should be in the range of $2.00 to $2.15.' London, 29 January 2004 Media Enquiries: Steve Brown/Edel McCaffrey (London) (020) 7304 5033/5034 Staffan Ternby (Sodertalje) (8) 553 26107 Rachel Blo-Baglin (Wilmington)om (302) 886 7858 Analyst/Investor Enquiries: Mina Blair-Robinson (London) (020) 7304 5084 Jonathan Hunt (London) (020) 7304 5087 Staffan Ternby (Sodertalje) (8) 553 26107 Ed Seage/Jorgen Winroth (US) (302) 886 4065/(212) 581 8720 Interviews with Sir Tom McKillop, Chief Executive and Jonathan Symonds, Chief Financial Officer are available in video/audio and text on http:// www.astrazeneca.com and http://www.cantos.com Business Highlights All narrative in this section refers to growth rates at constant exchange rates (CER) unless otherwise indicated Full Year Sales for the full year were unchanged in CER terms, as the strong sales performance of growth products offset the loss of $2.6 billion in US sales of PrilosecTM, ZestrilTM and NolvadexTM. Sales of growth and recently launched products increased 45 percent to $8.2 billion. The weaker US dollar lifted reported sales growth to 6 percent. Combined R&D and SG&A costs increased by an underlying 5.8 percent, but including the effects of currency movements, were up 14 percent on an 'as reported' basis. Operating profit was down 11 percent at CER. Earnings per share for the full year were $1.78 versus $1.64 ($1.84 before exceptional items) in 2002. Sales for the full year in the US were down 6 percent, following an aggregate 72 percent decline in PrilosecTM, ZestrilTM and NolvadexTM. Sales excluding these products grew 36 percent. Sales outside the US increased by 6 percent, helped by 15 percent growth in Asia Pacific. Sales in Europe were up 2 percent. NexiumTM sales reached $3.3 billion for the full year on strong growth in both the US (up 62 percent) and in the rest of the world (up 60 percent). Market share of total prescriptions in the US PPI market is now over 25 percent. Sales of Cardiovascular products increased by 3 percent, as a 50 percent decline in ZestrilTM was more than offset by a 19 percent increase in other products. Sales of SelokenTM/Toprol-XLTM were up 38 percent, exceeding the one billion dollar mark for the first time. AtacandTM sales were up 21 percent. CrestorTM added $129 million in sales from its first launches (25 countries to date), including $62 million since launch in the US in September. Across all launch markets the Company estimates that more than 1.5 million prescriptions have been written for CrestorTM so far. In the week ending 16 January, CrestorTM share of new prescriptions in the US statin market reached 4.6 percent. In December, ExantaTM received its first regulatory approval (in France) for the prevention of venous thromboembolic events in major orthopaedic surgery. France will now act as the reference member state for seeking approval in the European Union via the Mutual Recognition Procedure for this indication. Also in December, regulatory submissions were made in Europe and in the US for the first key chronic indications, including the prevention of stroke associated with atrial fibrillation. Respiratory product sales were up 15 percent. SymbicortTM sales were $549 million, mostly in Europe, as further market share gains were fueled by approval for treatment of chronic obstructive pulmonary disease and by the appeal of its unique adjustable maintenance dose regimen in the treatment of asthma. Growth in the US for PulmicortTM RespulesTM and RhinocortTM Aqua also contributed to the strong performance of the Respiratory franchise. Sales of Oncology products increased 8 percent despite generic erosion for NolvadexTM in the US. CasodexTM sales were up 22 percent overall on strong growth in markets outside the US. ArimidexTM sales were up 46 percent on increased usage in early breast cancer. IressaTM sales reached $228 million for the full year, with sales of just over $100 million each in Japan and the US. In the US, more than 42,000 retail prescriptions have been dispensed for IressaTM since launch in May 2003. Neuroscience product sales were up 12 percent, as SeroquelTM continued strong growth in the US (up 22 percent) and in the rest of the world (up 45 percent). Earlier this month the US FDA approved SeroquelTM for use in the treatment of acute bipolar mania. Fourth Quarter Sales in the fourth quarter were down by 8 percent in CER terms. Exchange rate movements against the US dollar resulted in a reported sales decline of just 1 percent. As expected, fourth quarter sales in the US were affected not only by the ongoing generic competition for PrilosecTM, ZestrilTM and NolvadexTM , but also by the projected unwinding of wholesaler stocks, which had been estimated to be around $300 million higher than normal at the end of the third quarter (chiefly in NexiumTM and Toprol-XLTM). At the end of the year, the Company believes wholesaler inventory across the product range that can be considered above normal has been reduced to well under $100 million. Fourth quarter sales for NexiumTM in the US increased by 12 percent, which was below the prescription trend, resulting in normal inventories at the end of the year. Substantial destocking also occurred for Toprol-XLTM (US sales down 21 percent versus last year's fourth quarter), but levels still remain higher than normal at year end. Sales outside the US in the fourth quarter increased 7 percent at CER, on growth in Europe (up 5 percent) and Asia Pacific (up 8 percent). R&D and SG&A were up 8 percent at CER in the fourth quarter and, set against the fourth quarter sales decline, resulted in operating profits down 26 percent (21 percent as reported with currency benefit of 5 percentage points included). Earnings per share in the fourth quarter were $0.38 compared with $0.25 ($0.45 before exceptional items) in 2002. Future Prospects Continued good performance from the Company's newer products should deliver strong sales and profit growth over the next several years, as the impact of generic erosion on the business diminishes. The Company believes that its financial performance over this period is likely to rank amongst the best in the global peer group of large capitalisation pharmaceutical companies. For 2004, on the basis of current exchange rates, the Company anticipates earnings per share in the range of $2.00 to $2.15 per share.The outcome is sensitive to exchange rate fluctuations and the sales performance attained for NexiumTM, CrestorTM and SeroquelTM. Disclosure Notice: The preceding forward-looking statements relating to expectations for earnings and business prospects for AstraZeneca PLC are subject to risks and uncertainties, which may cause results to differ materially from those set forth in the forward-looking statements. These include, but are not limited to: the rate of growth in sales of generic omeprazole in the US, continued growth in currently marketed products (in particular CrestorTM, NexiumTM, SeroquelTM, SymbicortTM, ArimidexTM and IressaTM), the successful registration and launch of ExantaTM, the growth in costs and expenses, interest rate movements, exchange rate fluctuations and the tax rate. For further details on these and other risks and uncertainties, see AstraZeneca PLC's Securities and Exchange Commission filings, including the 2002 Annual Report on Form 20-F. Sales All narrative in this section refers to growth rates at constant exchange rates (CER) unless otherwise indicated Gastrointestinal Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 LosecTM/ PrilosecTM 528 1,115 -58 2,565 4,623 -49 NexiumTM 836 686 +17 3,302 1,978 +62 Total 1,387 1,819 -29 5,943 6,664 -16 • In the US, sales of NexiumTM for the full year increased by 62 percent to $2,477 million. Total prescriptions for NexiumTM were up 46 percent and its share of total prescriptions in the US PPI market grew by nearly 5 percentage points over the course of the year, to 25.3 percent in December. • US sales for NexiumTM in the fourth quarter were up 12 percent as high wholesaler inventories following strong third quarter stocking were unwound to normal levels by year end. • Sales of NexiumTM outside the US increased by 60 percent for the full year, with excellent growth in the major markets in Europe, particularly France, Germany and the UK and a strong performance in Australia. • On 14 January 2004 the Company announced that the European Mutual Recognition Procedure for the intravenous formulation of NexiumTM had been successfully completed. An application for approval in the US is under review by the FDA. • US sales of PrilosecTM for the full year declined by 70 percent, in line with the decline in prescriptions. At the end of the year, PrilosecTM share of total prescriptions for omeprazole had fallen to 27.4 percent, with the balance held by generic products. • In markets outside the US, sales of LosecTM continued to grow strongly in Japan (up 39 percent) but otherwise sales were down in all major markets, resulting in a 16 percent decline. Cardiovascular Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 SelokenTM / Toprol-XLTM 246 263 -10 1,280 901 +38 AtacandTM 207 160 +18 750 569 +21 PlendilTM 157 139 +8 540 489 +5 ZestrilTM 136 144 -15 478 877 -50 CrestorTM 41 - n/m 129 - n/m Total 990 894 +3 3,910 3,569 +3 • For the full year, worldwide sales of SelokenTM/Toprol-XLTM exceeded one billion dollars for the first time, on continued strong growth in the US (up 47 percent). • Total prescriptions for Toprol-XLTM in the US increased by 25 percent, and market share of total beta blocker prescriptions reached 26.2 percent in December, up 2.6 points versus last year. • As anticipated, US sales for Toprol-XLTM in the fourth quarter (down 21 percent) were affected by wholesaler destocking. At the end of the year, however, wholesaler inventories remained higher than normal. • AtacandTM sales for the full year increased by 28 percent in the US, and by 18 percent in the markets outside the US, which account for nearly two-thirds of global AtacandTM sales. US sales growth exceeded growth in total prescriptions, indicating some increase in wholesaler inventories. • CrestorTM sales for the full year were $129 million, including $62 million in the US. • Since its first launch in the Netherlands in February, the Company estimates that more than 750,000 patients have taken CrestorTM and over 1.5 million prescriptions have been dispensed. Post marketing surveillance confirms excellent tolerability for CrestorTM, with a safety profile comparable to the other marketed statins. • The early launch markets for CrestorTM included the Netherlands, Canada and the UK. Based on the most recent market research data, CrestorTM share of total prescriptions in these markets has reached 8.2 percent (Netherlands), 6.9 percent (Canada) and 2.9 percent (UK) respectively. • In the US, CrestorTM was launched in mid-September. In the week ending 16 January, CrestorTM share of new prescriptions in the US statin market was 4.6 percent, a good start in a highly competitive market. CrestorTM dynamic share of new statin treatments (new and switch therapy only) is 13.7 percent. Respiratory Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 SymbicortTM 172 105 +43 549 299 +61 PulmicortTM 294 237 +17 968 812 +12 RhinocortTM 92 76 +17 364 299 +19 AccolateTM 31 52 -42 107 144 -28 OxisTM 29 29 -10 120 120 -12 Total 661 537 +14 2,261 1,818 +15 • SymbicortTM sales for the full year increased 61 percent to $549 million, as the product continues to gain share in the rapidly growing market for fixed combination asthma treatments. Launches for the chronic obstructive pulmonary disease indication as well as promotion of its unique adjustable maintenance dose regimen for asthma treatment are fuelling this growth. • On 9 December the Company announced submission of a regulatory application in the European Union for the new asthma treatment concept SymbicortTM Single inhaler Therapy (SiT), which is a further development of SymbicortTM adjustable maintenance dosing. SymbicortTM Single inhaler Treatment, once approved, will make asthma treatment more convenient for both the physician and the patient. • PulmicortTM sales for the full year increased by 12 percent as a result of growth in the US market (up 41 percent). PulmicortTM RespulesTM accounts for most of this growth, with total prescriptions in the US market up 32 percent for the year. • Sales growth for RhinocortTM Aqua in the US (up 58 percent) accounts for nearly all of the 19 percent increase in global RhinocortTM sales for the full year. Oncology Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 CasodexTM 207 184 +2 854 644 +22 ZoladexTM 239 206 +5 869 794 - ArimidexTM 147 92 +47 519 331 +46 IressaTM 92 41 +114 228 67 +227 FaslodexTM 21 16 +31 77 35 +120 NolvadexTM 40 138 -74 178 480 -66 Total 750 681 +1 2,743 2,369 +8 • CasodexTM sales outside the US increased by 23 percent for the full year, on continued penetration into the treatment of early prostate cancer. Sales in Japan were up 28 percent, with good growth in Germany and Italy contributing to a 20 percent increase in Europe. • In the US, the market for anti-androgen therapy in the treatment of advanced prostate cancer is quite mature; estimated underlying demand for CasodexTM was unchanged for the year. Reported sales growth of 18 percent reflects wholesaler destocking that occurred in 2002. • ArimidexTM is the leading aromatase inhibitor for the treatment of breast cancer. Approval for use in the adjuvant treatment of early breast cancer has been granted in 57 countries. Sales for the full year increased by 47 percent in the US and by 45 percent in the rest of the world, including a 61 percent increase in Japan. • FaslodexTM sales reached $77 million for the full year, virtually all in the US market. Formal approval in the European Union for FaslodexTM is expected shortly, with first launches anticipated in the second quarter. • IressaTM sales were $228 million for the full year, with sales evenly split between Japan ($101 million) and the US ($102 million). In December alone, more than 7,300 retail prescriptions were dispensed for IressaTM in the US, bringing the total to over 42,000 since launch in May. Neuroscience Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 SeroquelTM 428 357 +17 1,487 1,145 +27 ZomigTM 104 94 +4 349 328 -1 DiprivanTM 119 117 -3 458 443 -2 Local anaesthetics 122 121 -9 466 432 - Others 19 16 +6 73 70 -7 Total 792 705 +7 2,833 2,418 +12 • Sales of SeroquelTM in markets outside the US increased 44 percent for the full year. Sales in Europe were up 40 percent and sales in Japan rose 67 percent. • In the US, SeroquelTM sales reached $1,134 million for the full year, an increase of 22 percent. Total prescriptions for SeroquelTM in the US were up 34 percent for the year. SeroquelTM share of total prescriptions in the US antipsychotic market reached a new high at 21.2 percent in December, up 3.4 points versus last year. SeroquelTM was the only product among the three leading brands to increase its market share in 2003. • SeroquelTM prescriptions grew by 33 percent in the US in the fourth quarter. Sales growth was 16 percent versus the fourth quarter 2002, which included some increases in wholesaler stocking. • On 12 January 2004 the Company announced that the US FDA approved SeroquelTM for the treatment of acute bipolar mania. • ZomigTM sales for the full year increased 7 percent outside the US, and were down 8 percent in the US market. From 1 January 2004 Medpointe Inc., a specialty pharmaceutical company, has assumed responsibility to promote and sell the ZomigTM family of prescription migraine products in the US, including ZomigTM Nasal Spray, which was launched in the fourth quarter 2003. Geographic Sales Fourth Quarter CER % Full Year CER % 2003 2002 2003 2002 US 2,044 2,564 -20 8,747 9,351 -6 Europe 1,846 1,528 +5 6,709 5,695 +2 Japan 356 314 +3 1,189 977 +14 RoW 629 495 +14 2,204 1,818 +16 • In the US, sales for the full year (excluding the three products which faced generic erosion-PrilosecTM, ZestrilTM and NolvadexTM) increased 36 percent, holding the decline in overall sales to 6 percent. Growth products with strong performances included NexiumTM (up 62 percent), Toprol-XLTM (up 47 percent), and SeroquelTM (up 22 percent). In addition, IressaTM and CrestorTM were launched in the US in 2003. • Sales in Europe increased 2 percent for the full year, as strong sales growth for NexiumTM (up 55 percent), SymbicortTM (up 53 percent), SeroquelTM (up 40 percent), and the oncology products (up 18 percent) more than offset declines in LosecTM, ZestrilTM and PulmicortTM. • Sales in Japan were up 14 percent for the full year, as a result of increases in LosecTM (up 39 percent), SeroquelTM (up 67 percent), and a strong oncology portfolio (up 16 percent). • Sales in the rest of the world increased by 16 percent for the full year, with good growth achieved in China, Mexico and Australia. Operating Review All narrative in this section refers to growth rates at constant exchange rates (CER) unless otherwise indicated Full Year Reported sales grew by 6 percent and operating profits declined by 6 percent. At constant exchange rates sales were unchanged and operating profit declined by 11 percent. Currency movements continued to have a significant effect in 2003 as, compared with average 2002 rates, the US dollar weakened against the euro (17 percent), benefiting sales, and also against the Swedish krona (17 percent) and sterling (9 percent), increasing operating costs. Operating margin fell from 24.4 percent to 21.8 percent. Currency had a neutral effect on operating margin as a positive impact on gross margin was offset by the negative effect on SG&A and R&D costs as a percentage of sales. Gross margin increased 1.6 percentage points from 74.7 percent to 76.3 percent as a result of three factors: lower payments to Merck (related to proportionally lower US sales of products subject to these contingent payments) improved margin by 1.7 percentage points; underlying costs of sales increased by 0.7 percentage points; and the remainder was largely explained by exchange benefits. In aggregate R&D and SG&A grew by just under 6 percent in CER terms, with currency movements adding a further 8 percent. Against unchanged sales, both R&D and SG&A increased as a percentage of sales and exchange added a further 0.6 percentage points to these lines in aggregate. R&D increased by 1.1 percentage points to 18.3 percent. SG&A grew by 2.8 percentage points to 36.4 percent of sales as a result of the launches of CrestorTM and some field force increases in Europe and Japan. Other income was $43 million lower than last year, which included the gain on the disposal of SularTM marketing rights in the first quarter 2002. Fourth Quarter Reported sales declined by 1 percent and operating profits by 21 percent. At constant exchange rates sales fell by 8 percent and operating profit by 26 percent. Operating margin fell from 21.9 percent to 17.4 percent. Overall, currency was neutral on margin. Gross margin increased by 3.9 percentage points from 74.4 percent to 78.3 percent. Reduced payments to Merck following low PrilosecTM sales and destocking of NexiumTM and Toprol-XLTM accounted for 3.0 percentage points of this improvement, 0.7 percentage points were accounted for by underlying cost of sales and the balance being exchange. In aggregate R&D and SG&A grew by 8 percent in CER terms, with currency movements adding a further 9 percent. R&D and SG&A increased as a percentage of sales on increased spending set against the decline in sales versus the strong fourth quarter 2002, and currency effects. R&D increased by 3.2 points to 21.4 percent, as the phasing of spending was weighted toward the fourth quarter, which included several up-front payments for collaboration agreements signed in December and recruitment of additional staff in Discovery Research and Development. SG&A grew by 6.1 points to 40.0 percent of sales as a result of spending in support of the launches of new products. Wholesaler Stocking Wholesaler stocking continues to have an effect on the quarterly phasing of sales. As expected, wholesaler inventories unwound this quarter from an excess at the end of quarter three estimated at around $300 million to well under $100 million. For the year as a whole we estimate that excess wholesaler inventories had little or no effect on sales growth. Interest Net interest and dividend income in the quarter was $20 million, resulting in $91 million for the full year. Both the quarter and the full year benefited in comparison with 2002, as several small exchange and market revaluation losses in 2002 were absent in 2003. Taxation The effective tax rate for the fourth quarter was 26.0 percent, bringing the rate for the full year to 27.2 percent compared with 26.8 percent in 2002. In the fourth quarter AstraZeneca concluded a negotiated settlement with the UK and the US Governments covering all tax liabilities potentially arising from transfer pricing in respect of ex-Zeneca products for the years 1987 to 2001. Cash Flow Cash generated from operating activities before exceptional cash outflows was $4,617 million compared with $5,686 million in 2002. The principal cause of this decline was an increase in working capital of $1,101 million compared to a decrease of $305 million in 2002. Debtors increased by $540 million, partly due to higher invoiced sales in December in the US compared with 2002 and partly due to a higher proportion of sales from Europe where average credit terms are longer than in the US. The stronger European and Japanese currencies also increased the cash flow effect compared with last year. In addition, prepayments into pension funds increased, in particular a one-off payment of $165 million to the UK fund. Inventories increased by $131 million in support of CrestorTM launches and other rapidly growing products while inventories of mature products declined. Creditors have fallen by $430 million, partly due to a reduction in payables to Merck, but also due to the settlement of several one-off items notably commitments to pension funds in the US and Sweden at the end of 2002. Cash expenditure on exceptional items increased to $391 million principally as a result of the settlement of $355 million in respect of the ZoladexTM investigation. Tax paid was $886 million, including the transfer pricing settlement which had been provided for in previous years. Capital expenditures including intangible assets and new fixed asset investments totalled $1,597 million. Without the effect of exchange movements, expenditure on tangible fixed assets is slightly lower than in 2002. The cash inflow in respect of the disposal of Marlow Foods contributed $80 million in the year. After accounting for dividends paid of $1,222 million and net share repurchases of $1,107 million there was a $348 million decrease in net cash funds, which totalled $3,496 million at 31 December 2003. Dividends The Board has recommended a 15 percent increase in the second interim dividend to $0.54 (29.4 pence, 3.91 SEK) to be paid on 6 April 2004. This brings the dividend for the full year to $0.795 (45.3 pence, 5.98 SEK), an increase of 13.6 percent. It is the Board's intention that subsequently, dividends will increase broadly in line with earnings growth whilst bringing dividend cover to around the middle of the two to three times range. Share Repurchase Programme During the quarter 11.7 million shares were repurchased for cancellation at a total cost of $547 million, bringing the total for the year to 27.2 million shares at a total cost of $1,154 million. This was the final phase of share repurchases under the $4 billion programme that commenced in August 1999. Under this programme the total number of shares repurchased for cancellation stands at 92.8 million at an aggregate cost of $3,959 million. The Board has approved a new programme of share repurchases of $4 billion to be completed by the end of 2005, assuming continued market access and the absence of strategic uses for cash. The total number of shares that remain in issue at 31 December 2003 is 1,693 million. Upcoming Milestones and Key Events 29 April Announcement of first quarter results 29 April Annual General Meeting 22 July Announcement of second quarter results 6 October Annual Business Review meeting 21 October Announcement of third quarter and nine months results Sir Tom McKillop Chief Executive This information is provided by RNS The company news service from the London Stock Exchange

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