Final Results - Part 2 of 2

AstraZeneca PLC 29 January 2004 Consolidated Profit & Loss Account For Continuing Operations 2003 2002 For the year ended 31 December $m $m Sales 18,849 17,841 Cost of sales (4,469) (4,520) Distribution costs (162) (141) Research and development (3,451) (3,069) Selling, general and administrative expenses (6,856) (5,998) Other operating income 200 243 Operating profit before exceptional items 4,111 4,356 Exceptional items charged to operating profit - (350) Operating profit 4,111 4,006 Net interest and dividend income 91 31 Profit on ordinary activities before taxation 4,202 4,037 Profit before taxation before exceptional items 4,202 4,387 Exceptional items charged to profit before taxation - (350) Taxation (1,143) (1,177) Profit on ordinary activities after taxation 3,059 2,860 Attributable to minorities (23) (24) Net profit for the year 3,036 2,836 Dividends to Shareholders (1,350) (1,206) Earnings per Ordinary Share before exceptional items $1.78 $1.84 Earnings per Ordinary Share $1.78 $1.64 Diluted earnings per Ordinary Share $1.78 $1.64 Weighted average number of Ordinary Shares in issue (millions) 1,709 1,733 Diluted average number of Ordinary Shares in issue (millions) 1,712 1,735 Consolidated Profit & Loss Account For Continuing Operations 2003 2002 For the quarter ended 31 December $m $m Sales 4,875 4,901 Cost of sales (1,057) (1,253) Distribution costs (46) (39) Research and development (1,042) (892) Selling, general and administrative expenses (1,949) (1,661) Other operating income 68 18 Operating profit before exceptional items 849 1,074 Exceptional items charged to operating profit - (350) Operating profit 849 724 Net interest and dividend income 20 7 Profit on ordinary activities before taxation 869 731 Profit before taxation before exceptional items 869 1,081 Exceptional items charged to profit before taxation - (350) Taxation (226) (291) Profit on ordinary activities after taxation 643 440 Attributable to minorities (8) (12) Net profit for the period 635 428 Dividends to Shareholders (914) (808) Earnings per Ordinary Share before exceptional items $0.38 $0.45 Earnings per Ordinary Share $0.38 $0.25 Diluted earnings per Ordinary Share $0.38 $0.25 Weighted average number of Ordinary Shares in issue (millions) 1,699 1,723 Diluted average number of Ordinary Shares in issue (millions) 1,701 1,725 Consolidated Balance Sheet 2003 2002 At 31 December $m $m Fixed assets Tangible fixed assets 7,536 6,597 Goodwill and intangible assets 2,884 2,807 Fixed asset investments 220 46 10,640 9,450 Current assets Stocks 3,022 2,593 Debtors 5,960 4,845 Cash and short-term investments 3,951 4,688 12,933 12,126 Total assets 23,573 21,576 Creditors due within one year Short-term borrowings and current instalments of loans (152) (516) Other creditors (7,543) (7,699) (7,695) (8,215) Net current assets 5,238 3,911 Total assets less current liabilities 15,878 13,361 Creditors due after more than one year Loans (303) (328) Other creditors (52) (34) Provisions for liabilities and charges (2,266) (1,773) (2,621) (2,135) Net assets 13,257 11,226 Capital and reserves Shareholders' funds - equity interests 13,178 11,172 Minority equity interests 79 54 Shareholders' funds and minority interests 13,257 11,226 Statement of Total Recognised Gains and Losses 2003 2002 For the year ended 31 December $m $m Net profit for the financial year 3,036 2,836 Foreign exchange adjustments on consolidation, net of tax 1,427 1,106 Translation differences on foreign currency borrowings - 6 Tax on translation differences on foreign currency borrowings - (2) Total recognised gains and losses for the financial year 4,463 3,946 Consolidated Cash Flow Statement 2003 2002 For the year ended 31 December $m $m Cash flow from operating activities Operating profit before exceptional items 4,111 4,356 Depreciation and amortisation 1,290 960 (Increase)/decrease in working capital (1,101) 305 Other non-cash movements 317 65 Net cash inflow from operating activities before exceptional 4,617 5,686 items Outflow related to exceptional items (391) (93) Net cash inflow from operating activities 4,226 5,593 Returns on investments and servicing of finance 76 35 Tax paid (886) (795) Capital expenditure and financial investment (1,597) (1,543) Acquisitions and disposals 80 - Equity dividends paid to Shareholders (1,222) (1,234) Net cash inflow before management of liquid resources and 677 2,056 financing Management of liquid resources Net movement in short-term investments and fixed deposits 771 (806) Financing (1,452) (1,272) Decrease in cash in the year (4) (22) Reconciliation of Cash Flow to Net Cash Funds 2003 2002 For the year ended 31 December $m $m Net funds at 1 January 3,844 2,867 Net cash inflows before management of liquid resources and 677 2,056 financing Net cash outflows from share issues and repurchases (1,107) (1,154) Exchange 82 75 Net funds at 31 December 3,496 3,844 Notes to the Preliminary Announcement 1 BASIS OF PREPARATION AND ACCOUNTING POLICIES The results for the full year ended 31 December 2003 have been prepared in accordance with UK generally accepted accounting principles. The accounting policies applied are those set out in AstraZeneca PLC's 2002 Annual Report and Form 20-F. The results for the year ended 31 December 2003 presented in this preliminary announcement are extracted from, and are consistent with, those in the Group's audited financial statements for the year ended 31 December 2003 and those financial statements will be delivered to the Registrar of Companies following the Company's Annual General Meeting. Information in this preliminary announcement does not constitute statutory accounts of the Group within the meaning of Section 240 of the Companies Act 1985. Statutory accounts for the year ended 31 December 2002 have been filed with the Registrar of Companies. The auditor's report on those accounts was unqualified and did not contain any statement under Section 237 of the Companies Act 1985. 2 JOINT VENTURES AND ASSOCIATES The Group's share of joint venture's sales for the year ended 31 December 2003 amounted to $208 million and $191 million for the comparative period. Share of joint venture's operating profits for the year ended 31 December 2003 and 2002 amounted to $nil. 3 ANALYSIS OF EXCEPTIONAL ITEMS CHARGED TO OPERATING PROFIT 2003 2002 $m $m Accrual related to ZoladexTM investigations - 350 - 350 4 RECONCILIATION OF MOVEMENTS IN SHAREHOLDERS' FUNDS 2003 2002 For the year ended 31 December $m $m Shareholders' funds at beginning of year 11,172 9,586 Net profit for the year 3,036 2,836 Dividends to Shareholders (1,350) (1,206) 1,686 1,630 Issue of AstraZeneca PLC Ordinary Shares 47 36 Repurchase of AstraZeneca PLC Ordinary Shares (1,154) (1,190) Foreign exchange adjustments on consolidation, net of tax 1,427 1,110 Net addition to Shareholders' funds 2,006 1,586 Shareholders' funds at end of year 13,178 11,172 5 NET CASH FUNDS The table below provides an analysis of net cash funds and a reconciliation of net cash flow to movement in net cash funds. At 1 Jan Cash Other Exchange At 31 Dec 2003 flow non-cash movements 2003 $m $m $m $m $m Loans due after one year (328) 25 - - (303) Current instalments of loans (314) 320 - (6) - Total loans (642) 345 - (6) (303) Short-term investments 3,962 (771) - 27 3,218 Cash 726 (55) - 62 733 Short-term borrowings and overdrafts (202) 51 - (1) (152) 4,486 (775) - 88 3,799 Net cash funds 3,844 (430) - 82 3,496 Issue of AstraZeneca PLC Ordinary Shares (47) Repurchase of AstraZeneca PLC Ordinary 1,154 Shares Net cash inflow before management of 677 liquid resources and financing 6 FULL YEAR TERRITORIAL SALES ANALYSIS % Growth Full Year Full Year 2003 2002 Constant $m $m Actual Currency US 8,747 9,351 (6) (6) Canada 712 570 25 14 North America 9,459 9,921 (5) (6) France 1,454 1,140 28 9 UK 532 623 (15) (23) Germany 877 699 25 6 Italy 925 765 21 2 Sweden 304 285 7 (10) Europe others 2,617 2,183 20 4 Total Europe 6,709 5,695 18 2 Japan 1,189 977 22 14 Rest of World 1,492 1,248 20 18 Total 18,849 17,841 6 - 7 FOURTH QUARTER TERRITORIAL SALES ANALYSIS % Growth 4th 4th Quarter Quarter 2003 2002 Constant $m $m Actual Currency US 2,044 2,564 (20) (20) Canada 193 147 31 12 North America 2,237 2,711 (17) (18) France 396 320 24 6 UK 138 147 (6) (11) Germany 254 196 30 11 Italy 245 214 14 (3) Sweden 75 75 - (16) Europe others 738 576 28 12 Total Europe 1,846 1,528 21 5 Japan 356 314 13 3 Rest of World 436 348 25 14 Total 4,875 4,901 (1) (8) 8 FULL YEAR PRODUCT SALES ANALYSIS World US Full Year Full Year Constant Full Year 2003 2002 Actual Currency 2003 Actual $m $m Growth Growth $m Growth % % % Gastrointestinal: Losec 2,565 4,623 (45) (49) 867 (70) Nexium 3,302 1,978 67 62 2,477 62 Others 76 63 21 13 28 40 Total Gastrointestinal 5,943 6,664 (11) (16) 3,372 (23) Cardiovascular: Zestril 478 877 (45) (50) 97 (79) Seloken 1,280 901 42 38 909 47 Atacand 750 569 32 21 263 28 Plendil 540 489 10 5 237 13 Tenormin 342 370 (8) (15) 19 (63) Crestor 129 - n/m n/m 62 n/m Others 391 363 8 (4) 18 38 Total Cardiovascular 3,910 3,569 10 3 1,605 3 Respiratory: Pulmicort 968 812 19 12 509 41 Rhinocort 364 299 22 19 269 27 Symbicort 549 299 84 61 - - Accolate 107 144 (26) (28) 71 (32) Oxis 120 120 - (12) - - Others 153 144 6 (6) - - Total Respiratory 2,261 1,818 24 15 849 26 Oncology: Zoladex 869 794 9 - 174 (18) Casodex 854 644 33 22 212 18 Nolvadex 178 480 (63) (66) 41 (88) Arimidex 519 331 57 46 197 47 Iressa 228 67 240 227 102 n/m Faslodex 77 35 120 120 75 114 Others 18 18 - (6) - - Total Oncology 2,743 2,369 16 8 801 (11) Neuroscience: Seroquel 1,487 1,145 30 27 1,134 22 Zomig 349 328 6 (1) 163 (8) Diprivan 458 443 3 (2) 230 6 Local anaesthetics 466 432 8 - 106 (6) Others 73 70 4 (7) 18 (14) Total Neuroscience 2,833 2,418 17 12 1,651 14 Infection and Other: Merrem 346 285 21 16 63 7 Other Products 282 220 28 18 108 77 Total Infection and Other 628 505 24 16 171 43 Salick Health Care 281 233 21 21 281 21 Astra Tech 201 151 33 12 15 36 Marlow Foods* 49 114 n/m n/m 2 n/m Total 18,849 17,841 6 - 8,747 (6) * Sales 2003 until disposal n/m not meaningful 9 FOURTH QUARTER PRODUCT SALES ANALYSIS World US 4th 4th Constant 4th Quarter Quarter Actual Currency Quarter Actual 2003 2002 Growth Growth 2003 Growth $m $m % % $m % Gastrointestinal: Losec 528 1,115 (53) (58) 82 (88) Nexium 836 686 22 17 585 12 Others 23 18 28 22 10 43 Total Gastrointestinal 1,387 1,819 (24) (29) 677 (44) Cardiovascular: Zestril 136 144 (6) (15) 32 (30) Seloken 246 263 (6) (10) 144 (21) Atacand 207 160 29 18 66 20 Plendil 157 139 13 8 81 29 Tenormin 96 95 1 (8) 5 (50) Crestor 41 - n/m n/m 6 n/m Others 107 93 15 2 5 (600) Total Cardiovascular 990 894 11 3 339 (5) Respiratory: Pulmicort 294 237 24 17 161 34 Rhinocort 92 76 21 17 67 24 Symbicort 172 105 64 43 - - Accolate 31 52 (40) (42) 22 (46) Oxis 29 29 - (10) - - Others 43 38 13 - - - Total Respiratory 661 537 23 14 250 16 Oncology: Zoladex 239 206 16 5 46 (16) Casodex 207 184 13 2 25 (46) Nolvadex 40 138 (71) (74) 1 (99) Arimidex 147 92 60 47 44 38 Iressa 92 41 124 114 48 n/m Faslodex 21 16 31 31 20 25 Others 4 4 - - - - Total Oncology 750 681 10 1 184 (26) Neuroscience: Seroquel 428 357 20 17 338 16 Zomig 104 94 11 4 53 2 Diprivan 119 117 2 (3) 60 3 Local anaesthetics 122 121 1 (9) 21 (43) Others 19 16 19 6 5 - Total Neuroscience 792 705 12 7 477 7 Infection and Other: Merrem 104 69 51 41 23 188 Other Products 53 61 (13) (24) 9 (40) Total Infection and Other 157 130 21 10 32 39 Salick Health Care 81 63 29 29 81 29 Astra Tech 57 43 33 12 4 33 Marlow Foods* - 29 n/m n/m - n/m Total 4,875 4,901 (1) (8) 2,044 (20) * Sales 2003 until disposal n/m not meaningful Convenience Translation of Key Financial Information 2003 2002 2003 2002 2003 2002 For the quarter ended 31 December $m $m £m £m SEKm SEKm Total Sales 4,875 4,901 2,737 2,751 35,067 35,254 Operating profit before exceptional items (EI) 849 1,074 477 603 6,107 7,725 Profit before tax on continuing operations before EI 869 1,081 488 607 6,251 7,776 Net profit for the period 635 428 356 240 4,568 3,079 Earnings per Ordinary Share pre EI $0.38 $0.45 £0.21 £0.25 SEK 2.73 SEK 3.24 2003 2002 2003 2002 2003 2002 For the year ended 31 December $m $m £m £m SEKm SEKm Total Sales 18,849 17,841 10,581 10,015 135,585 128,334 Operating profit before exceptional items (EI) 4,111 4,356 2,308 2,445 29,571 31,334 Profit before tax on continuing operations before EI 4,202 4,387 2,359 2,463 30,226 31,557 Net profit for the year 3,036 2,836 1,704 1,592 21,839 20,400 Basic earnings per Ordinary Share $1.78 $1.64 £1.00 £0.92 SEK12.80 SEK 11.80 Earnings per Ordinary Share pre EI $1.78 $1.84 £1.00 £1.03 SEK12.80 SEK13.24 Dividend per Ordinary Share $0.795 $0.70 45.3p 43.2p SEK 5.98 SEK 6.20 Net cash inflow from operating activities 4,226 5,593 2,372 3,140 30,398 40,232 Decrease in cash (4) (22) (2) (12) (29) (158) Shareholders' funds - equity interests 31 December 13,178 11,172 7,397 6,271 94,792 80,362 Sterling (£) and Swedish krona (SEK) equivalents are shown for convenience and have been calculated using the current period end rates of $1= £0.561340 and $1= SEK 7.1932, respectively. Dividend per Ordinary Share is shown as the actual amount payable using the rates at the date of declaration of the dividend. Information for US Investors RECONCILIATION TO UNITED STATES ACCOUNTING PRINCIPLES The Group profit and loss account and Group balance sheet set out on pages 11, 12 and 13 are prepared in accordance with generally accepted accounting principles in the United Kingdom (UK GAAP) which differ in certain material respects from those generally accepted in the United States (US GAAP). The differences as they apply to AstraZeneca PLC are explained in the Group's 2002 Annual Report and Form 20-F. 2003 2002 Income attributable to Shareholders $m $m Net income for the year under UK GAAP 3,036 2,836 Adjustments to conform to US GAAP Purchase accounting adjustments (including goodwill and intangibles) - deemed acquisition of Astra - amortisation and other acquisition adjustments (952) (864) - others 59 55 Capitalisation, less disposals and amortisation of interest 17 46 Deferred taxation - on fair value of Astra 266 239 - others (91) (99) Pension and other post-retirement benefits expense (43) (46) Software costs capitalised (18) (46) Share based compensation (12) 33 Fair value of derivative financial instruments 10 93 Deferred income recognition 14 61 Unrealised losses on foreign exchange and others (18) (1) Net income in accordance with US GAAP 2,268 2,307 Net income per Ordinary Share under US GAAP (basic) $1.33 $1.33 Net income per Ordinary Share under US GAAP (diluted) $1.33 $1.33 RECONCILIATION TO UNITED STATES ACCOUNTING PRINCIPLES 31 Dec 31 Dec 2003 2002 Shareholders' equity $m $m Shareholders' equity under UK GAAP 13,178 11,172 Adjustment to conform to US GAAP Purchase accounting adjustments (including goodwill and intangibles) - deemed acquisition of Astra - goodwill 14,311 12,692 - tangible and intangible fixed assets 7,661 7,707 - others 145 86 Capitalisation, less disposals and amortisation of interest 255 238 Deferred taxation - on fair value of Astra (2,313) (2,305) - others (207) (159) Dividend 914 808 Pension and other post retirement benefits expense (534) (295) Software costs capitalised 46 64 Fair value of derivative financial instruments 109 99 Deferred income recognition - (14) Others 89 90 Shareholders' equity in accordance with US GAAP 33,654 30,183 Shareholder Information ANNOUNCEMENTS AND MEETINGS Announcement of first quarter 2004 results 29 April 2004 Annual General Meeting 2004 29 April 2004 Announcement of second quarter and half year 2004 results 22 July 2004 Annual Business Review 2004 6 October 2004 Announcement of third quarter and nine months 2004 21 October 2004 results DIVIDENDS The record date for the first interim dividend paid on 6 October 2003 (in the UK, Sweden and the US) was 22 August 2003. Ordinary Shares traded ex-dividend on the London and Stockholm Stock Exchanges from 20 August 2003. ADRs traded ex-dividend on the New York Stock Exchange from the same date. The record date for the second interim dividend for 2003 payable on 6 April 2004 (in the UK, Sweden and the US) will be 20 February 2004. Ordinary Shares will trade ex-dividend on the London and Stockholm Stock Exchanges from 18 February 2004. ADRs will trade ex-dividend on the New York Stock Exchange from the same date. Future dividends will normally be paid as follows: First interim Announced in July and paid in September Second interim Announced in January and paid in March TRADEMARKS The following brand names used in this preliminary announcement are trademarks of the AstraZeneca group of companies: Accolate Arimidex Astra Tech Atacand Casodex Crestor Diprivan Exanta Faslodex Iressa Losec Nexium Nolvadex Oxis Plendil Prilosec Pulmicort Pulmicort Respules Rhinocort Rhinocort Aqua Seloken Seroquel Symbicort Toprol-XL Zestril Zoladex Zomig ADDRESSES FOR CORRESPONDENCE Registrar and Depositary Registered Office Swedish Securities Register Centre Transfer Office for ADRs VPC AB The AstraZeneca Registrar JPMorgan Chase Bank 15 Stanhope Gate PO Box 7822 Lloyds TSB Registrars PO Box 43013 London S-103 97 Stockholm The Causeway Providence W1K 1LN Sweden Worthing RI 02940-3013 UK West Sussex US UK BN99 6DA Tel: +44 (0)121 415 7033 Tel: +1 (781) 575 4328 Tel: +44 (0)20 7304 5000 Tel: +46 (0)8 402 9000 CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS In order to utilise the 'Safe Harbor' provisions of the United States Private Securities Litigation Reform Act of 1995, AstraZeneca is providing the following cautionary statement. This Preliminary Report contains forward-looking statements with respect to the financial condition, results of operations and businesses of AstraZeneca. By their nature, forward-looking statements and forecasts involve risk and uncertainty because they relate to events and depend on circumstances that will occur in the future. There are a number of factors that could cause actual results and developments to differ materially from that expressed or implied by these forward-looking statements. These factors include, among other things, the loss or expiration of patents, marketing exclusivity or trade marks; exchange rate fluctuations; the risk that R&D will not yield new products that achieve commercial success; the impact of competition, price controls and price reductions; taxation risks; the risk of substantial product liability claims; the impact of any failure by third parties to supply materials or services; the risk of delay to new product launches; the difficulties of obtaining and maintaining governmental approvals for products; and the risk of environmental liabilities. This information is provided by RNS The company news service from the London Stock Exchange

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