Holding(s) in Company

AstraZeneca PLC
16 August 2006




Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 15 August 2006 we were informed by Barclays PLC, that on 9 August 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to
73,107,396 shares (4.68 per cent of the current issued ordinary capital) from
the previously notified level of 60,916,748 shares (3.88 per cent of the issued
ordinary capital at that time).




G H R Musker
Company Secretary
16 August 2006



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