Holding(s) in Company

AstraZeneca PLC
21 August 2006



Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 18 August 2006 we were informed by Barclays PLC, that on 15 August 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to
71,754,726 shares (4.60 per cent of the current issued ordinary capital) from
the previously notified level of 80,177,587 shares (5.14 per cent of the issued
ordinary capital at that time).


G H R Musker

Company Secretary

21 August 2006


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