Holding(s) in Company

AstraZeneca PLC
20 April 2006






Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 20 April 2006 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 18 April 2006 its interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to 202,010,016
shares (12.78 per cent of the current issued ordinary capital) from the
previously notified level of 198,942,168 shares (12.54 per cent of the issued
ordinary capital at that time).  The reason for this announcement is that,
within the said holding of 12.78 per cent of the issued ordinary capital of
AstraZeneca PLC, Capital Research and Management Company, an affiliate of The
Capital Group Companies, Inc., has increased its interest in these shares to
95,661,741 shares (6.05 per cent).





G H R Musker

Company Secretary

20 April 2006



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