Holding(s) in Company

AstraZeneca PLC
30 October 2006









Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 30 October 2006 we were informed by Wellington Management Company, LLP, a
registered investment advisor in the U.S., that on 30 October 2006 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 60,565,299
shares (3.92 per cent of the current issued ordinary capital) from the
previously notified level of 78,671,049 shares (4.98  per cent of the issued
ordinary capital at that time).



G H R Musker

Company Secretary

30 October 2006






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