Holding(s) in Company

AstraZeneca PLC
20 December 2007


TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

AstraZeneca PLC



2. Reason for the notification (place an X inside the appropriate bracket/s)

An acquisition or disposal of voting rights: (   )



An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: (    )



An event changing the breakdown of voting rights: (    )



Other (please specify) : ( change in issued share capital  )





3. Full name of person(s) subject to the notification obligation:

AXA S.A, 25 Avenue Matignon, 75008 Paris and its group companies



4. Full name of shareholder(s) (if different from 3.) :

.................



5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

17 December 2007



6. Date on which issuer notified:

18December 2007



7. Threshold(s) that is/are crossed or reached:

5%



8. Notified details:

.................



A: Voting rights attached to shares


Class/type of shares if possible              Situation previous to the Triggering transaction
using the ISIN CODE
                                  Number of shares                   Number of voting Rights
 Ordinary Shares                  75,243,691                         75,243,691
American Depositary Receipt       -                                  -







Resulting situation after the triggering transaction




Class/type of shares if     Number of shares         Number of voting rights           % of voting rights
possible using the ISIN
CODE
                            Direct                   Direct        Indirect            Direct      Indirect

Ordinary Shares              19,613,790              19,613,790    51,320,769           1.35       3.52
American Depositary Receipt -                        -             -                   -           -



B: Financial Instruments

Resulting situation after the triggering transaction


Type of         Expiration Date      Exercise/Conversion       Number of voting rights     % of voting rights
financial                            Period/ Date              that may be acquired if the
instrument                                                     instrument is exercised/
                                                               converted.




N/A



Total (A+B)
Number of voting rights        % of voting rights
70,934,559                     4.87%



9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

.................



Proxy Voting:



10. Name of the proxy holder:

.................



11. Number of voting rights proxy holder will cease to hold:

.................



12. Date on which proxy holder will cease to hold voting rights:

.................



13. Additional information:

.................



14. Contact name:

Justin Hoskins - Assistant Secretary



15. Contact telephone number:

020 7304 5112


                      This information is provided by RNS
            The company news service from the London Stock Exchange