Holding(s) in Company

AstraZeneca PLC
26 January 2005


Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies

On 26 January 2005 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 24 January 2005 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 220,352,313
shares (13.39 per cent of the current issued ordinary capital) from the
previously notified level of 229,717,719 shares (13.96 per cent).  Within the
said holding of 13.39 per cent of the issued ordinary capital of AstraZeneca
PLC, Capital Guardian Trust Company, an affiliate of The Capital Group
Companies, Inc., has decreased its interest in these shares to 82,190,937 shares
(4.99 per cent).

G H R Musker

Company Secretary

26 January 2005


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