Holding(s) in Company

AstraZeneca PLC
03 March 2005



Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 3 March 2005 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 1 March 2005 its interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 211,948,875
shares (12.94 per cent of the current issued ordinary capital) from the
previously notified level of 220,352,313 shares (13.39 per cent).


G H R Musker

Company Secretary

3 March 2005


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