Holding(s) in Company

AstraZeneca PLC
25 July 2006

Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 24 July 2006 we were informed by Barclays PLC, that on 19 July 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to
60,916,748 shares (3.88 per cent of the current issued ordinary capital) from
the previously notified level of 62,731,921 shares (4.00 per cent of the issued
ordinary capital at that time).





G H R Musker
Company Secretary
25 July 2006



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