Holding(s) in Company

AstraZeneca PLC
23 November 2005




Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 21 November 2005 we were informed by Wellington Management Company, LLP, a
registered investment advisor in the U.S., that on 18 November 2005 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to 79,723,952
shares (5.02 per cent of the current issued ordinary capital) from the
previously notified level of 79,405,884 shares (4.99  per cent of the issued
ordinary capital at that time).



G H R Musker

Company Secretary

23 November 2005






                      This information is provided by RNS
            The company news service from the London Stock Exchange