Holding(s) in Company

AstraZeneca PLC
18 December 2006









Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 15 December 2006 we were informed by Barclays PLC, that on 7 December 2006
its interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to
61,721,820 shares (4.03 per cent of the current issued ordinary capital) from
the previously notified level of 60,890,928 shares (3.90 per cent of the issued
ordinary capital at that time).





G H R Musker

Company Secretary

18 December 2006



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