Interim Results - Part 2 of 2

AstraZeneca PLC 27 July 2006 Consolidated Income Statement 2006 2005 For the six months ended 30 June $m $m Sales 12,805 11,875 Cost of sales (2,642) (2,723) Distribution costs (112) (104) Research and development (1,816) (1,725) Selling, general and administrative costs (4,405) (4,236) Other operating income 277 84 Operating profit 4,107 3,171 Finance income 400 316 Finance expense (254) (252) Profit before tax 4,253 3,235 Taxation (1,227) (968) Profit for the period 3,026 2,267 Attributable to: Equity holders of the Company 3,024 2,259 Minority interests 2 8 3,026 2,267 Basic earnings per $0.25 Ordinary Share $1.92 $1.38 Diluted earnings per $0.25 Ordinary Share $1.91 $1.38 Weighted average number of Ordinary Shares in issue (millions) 1,577 1,634 Diluted average number of Ordinary Shares in issue (millions) 1,581 1,634 Dividends declared in the period 1,453 1,061 Consolidated Income Statement 2006 2005 For the quarter ended 30 June $m $m Sales 6,625 6,132 Cost of sales (1,391) (1,313) Distribution costs (58) (54) Research and development (955) (860) Selling, general and administrative costs (2,290) (2,229) Other operating income 200 42 Operating profit 2,131 1,718 Finance income 199 197 Finance expense (121) (166) Profit before tax 2,209 1,749 Taxation (607) (525) Profit for the period 1,602 1,224 Attributable to: Equity holders of the Company 1,599 1,219 Minority interests 3 5 1,602 1,224 Basic earnings per $0.25 Ordinary Share $1.02 $0.75 Diluted earnings per $0.25 Ordinary Share $1.01 $0.75 Weighted average number of Ordinary Shares in issue (millions) 1,575 1,628 Diluted average number of Ordinary Shares in issue (millions) 1,580 1,628 Consolidated Balance Sheet As at As at As at 30 June 31 December 30 June 2006 2005 2005 $m $m $m ASSETS Non-current assets Property, plant and equipment 7,269 6,985 7,355 Intangible assets, including Goodwill 4,609 2,712 2,696 Other investments 125 256 221 Deferred tax assets 1,405 1,117 1,174 13,408 11,070 11,446 Current assets Inventories 2,211 2,206 2,663 Trade and other receivables 5,471 4,778 4,725 Other investments 1,020 1,624 398 Income tax receivable 273 183 201 Cash and cash equivalents 6,076 4,979 5,451 15,051 13,770 13,438 Total assets 28,459 24,840 24,884 LIABILITIES Current liabilities Interest bearing loans and borrowings (85) (90) (150) Trade and other payables (6,572) (5,466) (5,496) Income tax payable (1,748) (1,283) (1,151) (8,405) (6,839) (6,797) Non-current liabilities Interest bearing loans and borrowings (1,046) (1,111) (1,163) Deferred tax liabilities (1,775) (1,112) (1,163) Retirement benefit obligations (1,582) (1,706) (1,803) Provisions (317) (309) (306) Other payables (325) (72) (82) (5,045) (4,310) (4,517) Total liabilities (13,450) (11,149) (11,314) Net assets 15,009 13,691 13,570 EQUITY Capital and reserves attributable to equity holders of the Company Share capital 392 395 404 Share premium account 1,433 692 584 Other reserves 1,851 1,831 1,892 Retained earnings 11,234 10,679 10,597 14,910 13,597 13,477 Minority equity interests 99 94 93 Total equity 15,009 13,691 13,570 Consolidated Cash Flow Statement For the six months ended 30 June 2006 2005 $m $m Cash flows from operating activities Profit before taxation 4,253 3,235 Finance income and expense (146) (64) Depreciation and amortisation 588 630 (Increase)/decrease in working capital (352) 131 Other non-cash movements 115 45 Cash generated from operations 4,458 3,977 Interest paid (30) (13) Tax paid (1,007) (810) Net cash inflow from operating activities 3,421 3,154 Cash flows from investing activities Acquisition of business (213) - Movement in short term investments and fixed deposits 701 776 Purchase of property, plant and equipment (373) (411) Disposal of property, plant and equipment 16 73 Purchase of intangible assets (331) (38) Purchase of non-current asset investments (15) (6) Disposal of non-current asset investments 54 - Interest received 154 88 Dividends paid by subsidiaries to minority interest (4) (5) Net cash (outflow)/inflow from investing activities (11) 477 Net cash inflow before financing activities 3,410 3,631 Cash flows from financing activities Proceeds from issue of share capital 746 34 Repurchase of shares (1,627) (1,182) Dividends paid (1,442) (1,079) Movement in short term borrowings - 10 Net cash outflow from financing activities (2,323) (2,217) Net increase in cash and cash equivalents in the period 1,087 1,414 Cash and cash equivalents at the beginning of the period 4,895 3,927 Exchange rate effects 16 (28) Cash and cash equivalents at the end of the period 5,998 5,313 Cash and cash equivalents consists of: Cash and cash equivalents 6,076 5,451 Overdrafts (78) (138) 5,998 5,313 Consolidated Statement of Recognised Income and Expense For the six months ended 30 June 2006 2005 $m $m Profit for the period 3,026 2,267 Foreign exchange adjustments on consolidation 454 (968) Available for sale (losses)/gains taken to equity (20) 14 Actuarial gain/(loss) for the period 119 (125) Tax on items taken directly to reserves 23 38 Total recognised income and expense for the period 3,602 1,226 Attributable to: Equity holders of the Company 3,597 1,226 Minority interests 5 - 3,602 1,226 Independent review report to AstraZeneca PLC Introduction We have been instructed by the Company to review the financial information comprising the consolidated income statement, balance sheet, cash flow statement and statement of recognised income and expense for the six months ended and as at 30 June 2006 and notes 1 to 4 (set out on pages 12, 14 to 16 and 18 to 21, respectively). We have read the other information contained in the interim report and considered whether it contains any apparent misstatements or material inconsistencies with the financial information. This report is made solely to the Company in accordance with the terms of our engagement to assist the Company in meeting the requirements of the Listing Rules of the Financial Services Authority. Our review has been undertaken so that we might state to the Company those matters we are required to state to it in this report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Company for our review work, for this report, or for the conclusions we have reached. Directors' responsibilities The interim report, including the financial information contained therein, is the responsibility of, and has been approved by, the Directors. The Directors are responsible for preparing the interim report in accordance with the Listing Rules of the Financial Services Authority which require that the accounting policies and presentation applied to the interim figures should be consistent with those applied in preparing the preceding annual accounts except where any changes, and the reasons for them, are disclosed. Review work performed We conducted our review in accordance with guidance contained in Bulletin 1999/4 issued by the Auditing Practices Board for use in the UK. A review consists principally of making enquiries of group management and applying analytical procedures to the financial information and underlying financial data and, based thereon, assessing whether the accounting policies and presentation have been consistently applied unless otherwise disclosed. A review excludes audit procedures such as tests of controls and verification of assets, liabilities and transactions. It is substantially less in scope than an audit performed in accordance with International Statements on Auditing (UK and Ireland) and therefore provides a lower level of assurance than an audit. Accordingly, we do not express an audit opinion on the financial information. Review conclusion On the basis of our review we are not aware of any material modifications that should be made to the financial information as presented for the six months ended 30 June 2006. KPMG Audit Plc Chartered Accountants 8 Salisbury Square, London 27 July 2006 Notes to the Interim Financial Statements 1 BASIS OF PREPARATION AND ACCOUNTING POLICIES The unaudited financial statements for the six months ended 30 June 2006 have been prepared in accordance with International Accounting Standards and International Financial Reporting Standards (collectively 'IFRS') as adopted by the European Union (EU). Details of the accounting policies applied are those set out in AstraZeneca PLC's Annual Report and Form 20-F Information 2005. The information contained in Note 3 updates the disclosures concerning legal proceedings and contingent liabilities in the Company's Annual Report and Form 20-F Information 2005. These interim financial statements do not constitute statutory accounts of the Group within the meaning of Section 240 of the Companies Act 1985. Statutory accounts for the year ended 31 December 2005 have been filed with the Registrar of Companies. The auditors' report on those accounts was unqualified and did not contain any statement under Section 237 of the Companies Act 1985. 2 NET CASH FUNDS The table below provides an analysis of net cash funds and a reconciliation of net cash flow to the movement in net cash funds. At 1 Jan Cash Acquisitions Non-cash Exchange At 30 June 2006 flow $m movements movements 2006 $m $m $m $m $m Loans due after 1 year (1,111) - - 65 - (1,046) Other investments - current 1,624 (701) 157 (58) (2) 1,020 Cash and cash equivalents 4,979 1,081 - - 16 6,076 Overdrafts (84) 6 - - - (78) Short term borrowings (6) - - - (1) (7) 6,513 386 157 (58) 13 7,011 Net funds 5,402 386 157 7 13 5,965 Non-cash movements in the period consist of fair value adjustments under IAS 39. 3 LEGAL PROCEEDINGS AND COMMITMENTS AstraZeneca is involved in various legal proceedings considered typical to its businesses, including litigation relating to employment matters, product liability, commercial disputes, infringement of intellectual property rights, the validity of certain patents and securities law. The matters discussed below constitute the more significant developments since publication of the Company's Annual Report and Form 20-F Information 2005. Matters previously disclosed in respect of the first quarter of 2006 LosecTM / PrilosecTM (omeprazole) In February 2006, in the legal proceedings in Canada involving Apotex described in AstraZeneca's Annual Report and Form 20-F Information 2005, the Canadian Federal Court of Appeal upheld a lower court decision that precludes the issuance of a notice of compliance (marketing approval) in Canada for Apotex's generic omeprazole magnesium tablet product until the expiry of an AstraZeneca formulation patent relating to omeprazole in December 2008. This decision does not affect the continuing proceedings in the Supreme Court of Canada in which Apotex is appealing a lower court decision to quash Apotex's notice of compliance (marketing approval) for its generic omeprazole capsule product, nor does it affect the stay allowing Apotex to continue selling its omeprazole capsules in Canada pending a decision by the Supreme Court on Apotex's appeal. NexiumTM (esomeprazole) As previously disclosed, in March 2006 AstraZeneca commenced wilful infringement patent litigation in the US District Court for the District of New Jersey against IVAX Corporation and its affiliates in response to an Abbreviated New Drug Application filed by IVAX with the US Food and Drug Administration regarding IVAX's intent to market a generic version of NexiumTM in the US prior to the expiration of five AstraZeneca patents: 5,714,504; 5,877,192; 6,369,085; 6,428,810; and 6,875,872. The expiration dates for these patents range from 2014 through to 2019. AstraZeneca has full confidence in and will continue vigorously to defend and enforce its intellectual property rights protecting NexiumTM. SeroquelTM (quetiapine fumarate) Since 2003, AstraZeneca has been served with approximately 130 lawsuits in the US in which plaintiffs have alleged that they developed diabetes or other allegedly related injuries, and in some cases pancreatitis, as a result of taking SeroquelTM and/or other atypical anti-psychotics made by other pharmaceutical companies. Many of these cases were filed in Missouri in August 2005, days before Missouri's tort reform laws became effective. Eli Lilly, the maker of olanzapine, is a defendant in the majority of the cases served on AstraZeneca. Janssen Pharmaceutica and Bristol-Myers Squibb, the makers of other atypical anti-psychotics, are also defending a number of them. AstraZeneca has also been served with a putative nationwide class action complaint, which was filed in federal court in the Southern District of Illinois. It is very similar in form and content to the complaint filed in the US District Court for the Middle District of Florida in 2003 (Susan Zehel-Miller et al. v. AstraZenaca (sic), AstraZenaca Pharmaceuticals LP, (sic)) that sought certification of a nationwide class of SeroquelTM users and others, including individuals who were alleged to have developed diabetes as a result of using SeroquelTM. The federal court in Florida denied certification of the class in the Zehel-Miller case. In early 2005, after the plaintiffs' efforts in that case to secure appellate relief failed, the plaintiffs agreed to a voluntary dismissal of all of their claims with prejudice. AstraZeneca is also aware of approximately 360 other cases involving SeroquelTM (and in many instances, other atypical anti-psychotics) and allegations of diabetes or other allegedly related injuries that have been filed in various states, but these have not been served. Recently, two consortia of plaintiffs' lawyers filed motions with the Judicial Panel on Multidistrict Litigation seeking centralisation of all of the federal court cases alleging that SeroquelTM caused diabetes or other allegedly related injuries. AstraZeneca has opposed this motion. The Panel's decision is not expected before the end of May 2006. AstraZeneca intends to defend vigorously all of the pending cases relating to SeroquelTM. Toprol-XLTM (metoprolol succinate) Following issuance of the summary judgement decision that the Toprol-XLTM patents are invalid and unenforceable, AstraZeneca has been served with several putative class action complaints filed in the US District Court for the District of Delaware, one such action filed in the US District Court for the District of Massachusetts and one such action filed in the US District Court for the Southern District of Florida alleging that AstraZeneca monopolised the market for metoprolol succinate by filing patent litigation against KV Pharmaceutical Company, Andrx Pharmaceuticals LLC and Eon Labs Manufacturing Inc. asserting invalid and unenforceable patents in violation of US anti-trust laws. The complaints include those by plaintiffs purporting to represent the class of distributors who purchased Toprol-XLTM directly from AstraZeneca at allegedly supracompetitive prices and those by plaintiffs purporting to represent the class of consumers and third party payers who are indirect purchasers of Toprol-XLTM at allegedly supra-competitive prices. AstraZeneca has appealed the underlying judgment that the patents are invalid and unenforceable to the US Court of Appeals for the Federal Circuit. AstraZeneca also denies the allegations of the anti-trust complaints and will vigorously defend them. Matters disclosed in respect of the second quarter of 2006 NexiumTM (esomeprazole) As previously disclosed, AstraZeneca LP filed suit in October 2004 in the US District Court for the District of Delaware seeking declaratory judgement that its 'Better is Better' campaign for NexiumTM is not false or misleading advertising in violation of section 43(a) of the Lanham Act, a federal statute concerning false advertising claims. The action was taken in response to a letter from TAP Pharmaceuticals, Inc. demanding that AstraZeneca immediately withdraw the television commercial and other components of the direct-to-consumer advertising campaign for NexiumTM on the basis that they allegedly violated the statute. Having denied TAP's request for a preliminary injunction in December 2004, the court dismissed all of the claims for damages asserted by TAP in its counterclaims in May 2006 and dismissed most of TAP's claims for injunctive relief in June 2006. SeroquelTM (quetiapine fumarate) In the litigation involving atypical anti-psychotics including SeroquelTM referred to above, AstraZeneca has now been served with approximately 350 lawsuits in total in the US since 2003 in which plaintiffs have alleged that they developed diabetes or other allegedly related injuries, and in some cases pancreatitis, as a result of taking SeroquelTM and/or other atypical anti-psychotics made by other pharmaceutical companies. AstraZeneca is also aware of approximately 70 other cases involving SeroquelTM (and in many instances, other atypical anti-psychotics) and allegations of diabetes or other allegedly related injuries that have been filed in various states, but these have not been served. In July 2006, the Judicial Panel on Multidistrict Litigation agreed to plaintiffs' requests to consolidate the federal court cases involving Seroquel TM, selecting the judge recommended by AstraZeneca, Judge Anne Conway, Middle District of Florida. Two putative class action complaints involving SeroquelTM and allegations of diabetes or other allegedly related injuries were recently filed against AstraZeneca Canada Inc., as well as various affiliates, in the provinces of Quebec and British Columbia. AstraZeneca intends to defend vigorously all of the pending cases relating to SeroquelTM. ZestrilTM (lisinopril) In April 2006, the Federal Court of Canada ruled in favour of AstraZeneca and Merck & Co., Inc. in the patent infringement case brought against Apotex, Inc. alleging infringement of Merck's lisinopril patent in Canada. The judgment has been appealed and the appeal is scheduled to be heard in September 2006. General With respect to each of the legal proceedings described above, we are unable to make estimates of the loss or range of losses at this stage. We also do not believe that disclosure of the amount sought by plaintiffs, if that is known, would be meaningful with respect to those legal proceedings. Arrangements with Merck As described in more detail in the Annual Report and Form 20-F Information 2005, AstraZeneca has significant arrangements with Merck & Co., Inc. relating to certain of our products and development compounds. These arrangements include exit provisions from 2008 onwards and we regularly monitor the value of the benefits we expect to receive. The exit provisions are subject to a minimum overall net payment of $3.3 billion and will offer AstraZeneca unencumbered discretion in its operations in the US market (except in respect of PrilosecTM and NexiumTM) without the restrictions of various contractual obligations that are currently imposed as a result of Merck's interests, together with relief from contingent payment obligations. The projected value of the benefits to be obtained in 2008 depends on a number of factors including the future contributions from products that have already been launched, those that are due to be launched in the US and those that are in development, together with the further value that AstraZeneca can extract from greater freedom to operate in the US. 4 HALF YEAR TERRITORIAL SALES ANALYSIS % Growth 1st Half 1st Half 2006 2005 Constant $m $m Actual Currency US 5,959 5,243 14 14 Canada 513 488 5 (2) North America 6,472 5,731 13 12 France 834 874 (5) 2 UK 400 380 5 12 Germany 580 621 (7) - Italy 660 609 8 16 Sweden 156 162 (4) 5 Europe others 1,797 1,716 5 12 Total Europe 4,427 4,362 1 8 Japan 691 736 (6) 4 China 156 135 16 14 Rest of World 1,059 911 16 16 Total 12,805 11,875 8 11 5 SECOND QUARTER TERRITORIAL SALES ANALYSIS % Growth 2nd 2nd Quarter Quarter 2006 2005 $m $m Constant Actual Currency US 3,077 2,743 12 12 Canada 263 240 10 1 North America 3,340 2,983 12 11 France 419 423 (1) 3 UK 207 192 8 13 Germany 301 306 (2) 2 Italy 346 324 7 11 Sweden 78 82 (5) - Europe others 904 870 4 8 Total Europe 2,255 2,197 3 7 Japan 387 399 (3) 5 China 84 73 15 12 Rest of World 559 480 16 17 Total 6,625 6,132 8 10 6 HALF YEAR PRODUCT SALES ANALYSIS World US 1st 1st Actual Constant 1st Half Actual Half Half Growth Currency Growth Growth 2006 2005 2006 $m $m % % $m % Gastrointestinal: Nexium 2,472 2,259 9 11 1,656 9 Losec/Prilosec 700 865 (19) (16) 100 (24) Others 33 36 (8) (5) 5 (17) Total Gastrointestinal 3,205 3,160 1 3 1,761 7 Cardiovascular: Seloken/Toprol-XL 934 843 11 12 732 20 Crestor 867 590 47 48 491 45 Atacand 530 489 8 12 122 - Tenormin 161 175 (8) (3) 13 30 Zestril 153 165 (7) (3) 13 N/m Plendil 142 205 (31) (30) 11 (82) Others 143 160 (11) (6) 2 - Total Cardiovascular 2,930 2,627 12 14 1,384 21 Respiratory: Pulmicort 629 590 7 9 399 19 Symbicort 585 502 17 24 - - Rhinocort 187 204 (8) (8) 131 (11) Oxis 44 46 (4) - - - Accolate 39 41 (5) (5) 27 - Others 72 81 (11) (7) - - Total Respiratory 1,556 1,464 6 9 557 9 Oncology: Arimidex 714 553 29 34 284 27 Casodex 580 564 3 8 140 19 Zoladex 481 494 (3) 2 52 (15) Iressa 112 140 (20) (16) 8 (78) Faslodex 91 64 42 45 51 16 Nolvadex 45 60 (25) (20) 2 (33) Others 6 6 - - - - Total Oncology 2,029 1,881 8 13 537 10 Neuroscience: Seroquel 1,656 1,300 27 29 1,210 30 Local anaesthetics 272 262 4 9 49 58 Zomig 196 172 14 17 86 56 Diprivan 161 205 (21) (19) 51 (41) Others 29 35 (17) (14) 8 (20) Total Neuroscience 2,314 1,974 17 19 1,404 26 Infection and Other: Merrem 284 258 10 13 51 6 Other Products 133 189 (30) (26) 65 (42) Total Infection and Other 417 447 (7) (4) 116 (28) Aptium Oncology 181 165 10 10 181 10 Astra Tech 173 157 10 17 19 36 Total 12,805 11,875 8 11 5,959 14 7 SECOND QUARTER PRODUCT SALES ANALYSIS World US 2nd 2nd Actual Constant 2nd Actual Quarter Quarter Growth Currency Quarter Growth 2006 2005 % Growth 2006 % $m $m % $m Gastrointestinal: Nexium 1,283 1,204 7 8 865 5 Losec/Prilosec 356 438 (19) (17) 45 (38) Others 15 19 (21) (21) 2 (33) Total Gastrointestinal 1,654 1,661 - 1 912 2 Cardiovascular: Seloken/Toprol-XL 478 435 10 11 378 19 Crestor 480 317 51 51 271 47 Atacand 276 254 9 11 64 (3) Tenormin 85 92 (8) (4) 6 (14) Zestril 78 78 - 3 7 N/m Plendil 70 112 (38) (38) 5 (88) Others 73 82 (11) (7) 1 - Total Cardiovascular 1,540 1,370 12 13 732 20 Respiratory: Pulmicort 301 276 9 10 190 17 Symbicort 308 255 21 25 - - Rhinocort 102 112 (9) (9) 70 (14) Oxis 22 23 (4) (4) - - Accolate 21 13 62 62 15 150 Others 37 39 (5) (5) - - Total Respiratory 791 718 10 12 275 10 Oncology: Arimidex 379 297 28 31 156 28 Casodex 306 287 7 11 74 32 Zoladex 250 263 (5) (2) 28 (3) Iressa 62 59 5 8 4 (43) Faslodex 47 35 34 37 26 8 Nolvadex 24 32 (25) (22) 1 (67) Others 3 3 - - - - Total Oncology 1,071 976 10 13 289 20 Neuroscience: Seroquel 849 667 27 28 620 30 Local anaesthetics 140 135 4 7 25 79 Zomig 103 104 (1) 1 46 - Diprivan 72 98 (27) (25) 17 (59) Others 14 18 (22) (22) 4 (20) Total Neuroscience 1,178 1,022 15 16 712 22 Infection and Other: Merrem 143 127 13 14 22 16 Other Products 65 92 (29) (25) 32 (42) Total Infection and Other 208 219 (5) (3) 54 (27) Aptium Oncology 93 82 13 13 93 13 Astra Tech 90 84 7 11 10 25 Total 6,625 6,132 8 10 3,077 12 Information for US Investors RECONCILIATION TO UNITED STATES ACCOUNTING PRINCIPLES The consolidated income statement and balance sheet set out on pages 12 and 14 are prepared in accordance with IASs and IFRSs (collectively 'IFRS') as adopted by the European Union (EU), which differ in certain material respects from those accounting principles generally accepted in the United States (US GAAP). The differences as they apply to AstraZeneca PLC are explained in the Annual Report and Form 20-F Information 2005. The effects on income and shareholders' equity of the GAAP differences are shown below. 1st Half 1st Half Income attributable to Shareholders 2006 2005 $m $m Net income for the period under IFRS 3,024 2,259 Adjustments to conform to US GAAP Purchase accounting adjustments: - amortisation and depreciation (500) (530) - in-process research and development (504) - Capitalisation less disposals and amortisation of interest (11) (7) Pension and other post-retirement benefits (36) (39) Financial instruments (50) 40 In-licensed development intangibles (97) (5) Deferred taxation - on purchase accounting adjustments 139 147 - others (31) 71 Other 32 - Net income in accordance with US GAAP 1,966 1,936 Net income per Ordinary Share in accordance with US GAAP - basic $1.25 $1.19 Net income per Ordinary Share in accordance with US GAAP - diluted $1.24 $1.19 Shareholders' equity 30 June 30 June 2006 2005 $m $m Shareholders' equity under IFRS 14,910 13,477 Adjustments to conform to US GAAP Purchase accounting adjustments: - goodwill 14,221 13,676 - property, plant and equipment and intangible assets 5,003 5,790 - in-process research and development (426) - Capitalisation, less disposals and amortisation of interest 230 247 Pension and other post-retirement benefits 1,328 1,528 Financial instruments (44) 69 In-licensed development intangibles (212) (92) Deferred taxation - on purchase accounting adjustments (1,575) (1,781) - others (495) (575) Other 27 (1) Shareholders' equity in accordance with US GAAP 32,967 32,338 Shareholder Information ANNOUNCEMENTS AND MEETINGS Announcement of third quarter and nine months 2006 26 October 2006 results Announcement of fourth quarter and full year 2006 results 1 February 2007 DIVIDENDS The record date for the first interim dividend payable on 18 September 2006 (in the UK, Sweden and the US) is 11 August 2006. Ordinary shares will trade ex-dividend on the London and Stockholm Stock Exchanges from 9 August 2006. ADRs will trade ex-dividend on the New York Stock Exchange from the same date. Future dividends will normally be paid as follows: First interim Announced in July and paid in September Second interim Announced in January/February and paid in March TRADEMARKS The following brand names used in these interim financial statements are trademarks of the AstraZeneca Group of companies: Accolate Arimidex Astra Tech Atacand Casodex Crestor Diprivan Faslodex Iressa Losec Merrem Nexium Nolvadex Oxis Plendil Prilosec Pulmicort Pulmicort Respules Rhinocort Rhinocort Aqua Seloken Seroquel Symbicort Tenormin Toprol-XL Zestril Zoladex Zomig ADDRESSES FOR CORRESPONDENCE Registrar and Depositary Registered Office Swedish Securities Transfer Office for ADRs Registration Centre The AstraZeneca Registrar JPMorgan Chase Bank 15 Stanhope Gate VPC AB Lloyds TSB Registrars JP Morgan Service Center London PO Box 7822 The Causeway PO Box 3408 W1K 1LN SE-103 97 Stockholm Worthing South Hackensack UK Sweden West Sussex NJ 07606-3408 BN99 6DA US UK Tel: +44 (0)20 7304 5000 Tel: +46 (0)8 402 9000 Tel (freephone in UK): Tel (toll free in US): 0800 389 1580 888 697 8018 Tel (outside UK): Tel: +1 (201) 680 6630 +44 (0)121 415 7033 CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS In order to utilise the 'safe harbour' provisions of the US Private Securities Litigation Reform Act 1995, we are providing the following cautionary statement: These interim financial statements contain certain forward-looking statements about AstraZeneca. Although we believe our expectations are based on reasonable assumptions, any forward-looking statements may be influenced by factors that could cause actual outcomes and results to be materially different from those predicted. We identify the forward-looking statements by using the words ' anticipates', 'believes', 'expects', 'intends' and similar expressions in such statements. These forward-looking statements are subject to numerous risks and uncertainties. Important factors that could cause actual results to differ materially from those contained in forward-looking statements, certain of which are beyond control, include, among other things: the loss or expiration of patents, marketing exclusivity or trade marks; exchange rate fluctuations; the risk that R&D will not yield new products that achieve commercial success; the impact of competition, price controls and price reductions; taxation risks; the risk of substantial product liability claims; the impact of any failure by third parties to supply materials or services; the risk of delay to new product launches; the difficulties of obtaining and maintaining governmental approvals for products; the risk of failure to observe ongoing regulatory oversight; the risk that new products do not perform as we expect; and the risk of environmental liabilities. This information is provided by RNS The company news service from the London Stock Exchange

Companies

AstraZeneca (AZN)
UK 100

Latest directors dealings