Seroquel SR

AstraZeneca PLC 18 July 2006 AstraZeneca Submits an NDA For Sustained Release Formulation SEROQUEL SR(TM) For the Treatment of Schizophrenia AstraZeneca today announced the submission of a New Drug Application (NDA) to the US Food and Drug Administration for a sustained release (SR) once-daily formulation of SEROQUEL for the treatment of patients with schizophrenia. The clinical trials to support the US submission of SEROQUEL SR(TM) used a short titration period aimed at achieving a therapeutically effective dose by the second day of treatment. The Company also expects to make a SEROQUEL SR(TM) filing in the European Union towards the end of 2006. The SR formulation has patent protection to 2017. SEROQUEL(R) (quetiapine fumarate) has a well-established safety and efficacy profile and to date over 16 million people have been treated worldwide. SEROQUEL(R) has been licensed for the treatment of schizophrenia since 1997 and it is available in 85 countries for the treatment of this condition. SEROQUEL is also licensed in 73 countries for the treatment of mania associated with bipolar disorder. Following the recent regulatory submissions based on the BOLDER studies in bipolar depression, SEROQUEL is set to become the first medication to offer a single treatment effective at both poles of bipolar disease (depression and mania). SEROQUEL is the number one prescribed atypical antipsychotic in the United States, with global sales of almost $2.8 billion in 2005. Tuesday 18th July 2006 Media Enquiries: Edel McCaffrey, Tel: +44 (0) 207 304 5034 Steve Brown, Tel: +44 (0) 207 304 5033 Investor Relations: Mina Blair, Tel: +44 (0) 207 304 5084 Jonathan Hunt, Tel: +44 (0) 207 304 5087 Ed Seage, Tel: +1 302 886 4065 Jorgen Winroth, Tel +1 (212) 579 0506 -Ends- This information is provided by RNS The company news service from the London Stock Exchange

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