Transaction in Own Shares

AstraZeneca PLC
22 September 2005


                    REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 21 September 2005, it purchased for
cancellation 700,000 ordinary shares of AstraZeneca PLC at a price of 2573 pence
per share. Upon the cancellation of these shares, the number of shares in issue
will be 1,599,460,026.


G H R Musker
Company Secretary
22 September 2005


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