Transaction in Own Shares

AstraZeneca PLC
20 October 2006




                         REPURCHASE OF SHARES IN ASTRAZENECA PLC



Further to the announcement of its close period share repurchase programme,
AstraZeneca PLC announced that under the terms of that programme it purchased
for cancellation 376,600 ordinary shares of AstraZeneca PLC at a price of 3487
pence per share on 19 October 2006. Upon the cancellation of these shares, the
number of shares in issue will be 1,545,493,889.





G H R Musker
Company Secretary
20 October 2006


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