Transaction in Own Shares

AstraZeneca PLC
21 November 2006

REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share
repurchase programme for the month of November, AstraZeneca PLC announced that
under the terms of that programme it purchased for cancellation 375,879 ordinary
shares of AstraZeneca PLC at a price of 3020 pence per share on 20 November
2006. Upon the cancellation of these shares, the number of shares in issue will
be 1,539,000,885.



G H R Musker
Company Secretary
21 November 2006


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