Transaction in Own Shares

AstraZeneca PLC
24 November 2006

REPURCHASE OF SHARES IN ASTRAZENECA PLC





Further to the announcement of its irrevocable, non-discretionary share
repurchase programme for the month of November, AstraZeneca PLC announced that
under the terms of that programme it purchased for cancellation 380,515 ordinary
shares of AstraZeneca PLC at a price of 2982 pence per share on 23 November
2006.



In addition, AstraZeneca PLC announced that on the same date, it purchased for
cancellation 286,800 ordinary shares of AstraZeneca PLC at a price of 2978 pence
per share.



Upon the cancellation of all of the shares purchased on that date, the number of
shares in issue will be 1,537,614,835.





G H R Musker

Company Secretary

24 November 2006


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