Transaction in Own Shares

AstraZeneca PLC
27 November 2006




               REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share
repurchase programme for the month of November, AstraZeneca PLC announced that
under the terms of that programme it purchased for cancellation 381,031 ordinary
shares of AstraZeneca PLC at a price of 2978 pence per share on 24 November
2006. Upon the cancellation of these shares, the number of shares in issue will
be 1,537,233,804.


G H R Musker
Company Secretary
27 November 2006


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