Transaction in Own Shares

AstraZeneca PLC
29 November 2006


                    REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share
repurchase programme for the month of November, AstraZeneca PLC announced that
under the terms of that programme it purchased for cancellation 386,675 ordinary
shares of AstraZeneca PLC at a price of 2932 pence per share on 28 November
2006.

In addition, AstraZeneca PLC announced that on the same date, it purchased for
cancellation 500,000 ordinary shares of AstraZeneca PLC at a price of 2935 pence
per share.

Upon the cancellation of all of the shares purchased on that date, the number of
shares in issue will be 1,535,962,024.


G H R Musker
Company Secretary
29 November 2006


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