Transaction in Own Shares

AstraZeneca PLC
10 September 2007


REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 7 September 2007, it purchased for
cancellation 739,098 ordinary shares of AstraZeneca PLC at a price of 2386 pence
per share.

Some of these shares were purchased under the terms of the previously announced
irrevocable, non-discretionary share repurchase programme for the period 2 July
2007 to 31 October 2007.

Upon the cancellation of these shares, the number of shares in issue will be
1,479,811,733.

G H R Musker

Company Secretary

10 September 2007


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