Transaction in Own Shares

AstraZeneca PLC
01 December 2005



                    REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 30 November 2005, it purchased for
cancellation 1,000,000 ordinary shares of AstraZeneca PLC at a price of 2677
pence per share. Upon the cancellation of these shares, the number of shares in
issue will be 1,584,608,337.


G H R Musker
Company Secretary
1 December 2005


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