Major Interest in Shares

Banco Santander S.A.
28 January 2008


NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

BANCO SANTANDER, S. A.....................................

2. Name of shareholder having a major interest

CAPITAL RESEARCH AND MANAGEMENT COMPANY ('CRMC'). The shares reported in this 
disclosure are not owned by CRMC for its own account but for the mutual funds 
under its discretionary investment management.

3. Please state whether notification indicates that it is in respect of holding
 of the shareholder named in 2 above or in respect of a non-beneficial interest
 or in the case of an individual holder if it is a holding of that person's 
spouse or children under the age of 18

AS IN 2 ABOVE.........................................................

4. Name of the registered holder(s) and, if more than one holder, the number of 
shares held by each of them

AS IN 2 ABOVE.........................................................

5. Number of shares / amount of stock acquired

............................................................

6. Percentage of issued class

............................................................

7. Number of shares / amount of stock disposed

2,311,418 ....................................................................

8. Percentage of issued class

0.037%............................................................

9. Class of security

ORDINARY SHARES OF 0.50 EURO NOMINAL VALUE EACH .....................

10. Date of transaction

ON 21 JANUARY 2008......................................................

11. Date company informed

ON 22 JANUARY 2008......................................................

12. Total holding following this notification

308,495,447 SHARES...................................................

13. Total percentage holding of issued class following this notification

4.953% TAKING INTO ACCOUNT TREASURY SHARES WHEN CALCULATING PERCENTAGE. 
4.933  % NOT TAKING INTO ACCOUNT TREASURY SHARES..................

14. Any additional information



15. Name of contact and telephone number for queries

ILIANA BROSCHAT ; + (34) 91 289 9387...................................

16. Name and signature of authorised company official responsible for making 
this notification

JOSE MANUEL DE ARALUCE................................................

Date of notification

ON 28 JANUARY 2008.................................................

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