Rule 8.3 - SKYEPHARMA PLC

FORM 8.3 DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE (Rule 8.3 of the City Code on Takeovers and Mergers) 1. KEY INFORMATION Name of person dealing BARCLAYS PLC (Note 1) Company dealt in SKYEPHARMA PLC Class of relevant security GBP 0.10 to which the dealings being disclosed relate (Note 2) Date of dealing 13 DECEMBER 2005 2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE (a) Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3) Long Short Number (%) Number (%) (1) Relevant 17,907,351 (2.38%) 746,447 (0.10%) securities (2) Derivatives 1,045,678 (0.14%) 1,323,423 (0.18%) (other than options) (3) Options and 0 (0.00%) 0 (0.00%) agreements to purchase/sell Total 18,953,029 (2.51%) 2,069,870 (0.27%) (b) Interests and short positions in relevant securities of the company, other than the class dealt in (Note 3) Class of relevant security: Long Short Number Number (%) (%) (1) Relevant securities (2) Derivatives (other than options) (3) Options and agreements to purchase/sell Total (c) Rights to subscribe (Note 3) Class of relevant security: Details 3. DEALINGS (Note 4) (a) Purchases and sales Purchase/sale Number of Securities Price per unit (GBP) Purchase 14,146 0.5100 Purchase 1,023 0.5103 Sale 62,299 0.5109 (b) Derivatives transactions (other than options) Product Long/Short Number of Securities Price Per name, (Note 6) (Note 7) Unit (GBP) e.g. CFD CFD Long 62,299 0.5109 CFD Short 1,023 0.5103 (c) Options transactions in respect of existing securities (i) Writing, selling, purchasing or varying Product Writing, Number of Exerc Type, Expir Option name, selling, securities ise e.g. y money e.g. call purchasin to which the price American date paid/rece option g, option , ived per varying relates European unit etc. (Note 7) etc. (Note 5) (ii) Exercising Product name, e.g. call Number of securities Exercise price per unit option (Note 5) (d) Other dealings (including new securities) (Note 4) Nature of transaction Details Price per unit (if (Note 8) applicable) (Note 5) 4. OTHER INFORMATIONS Agreements, arrangements or understandings relating to options or derivatives Full details of any agreement, arrangement or understanding between the person disclosing and any other person relating to the voting rights of any relevant securities under any option referred to on this form or relating to the voting rights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form is referenced. If none, this should be stated. Is a Supplemental Form 8 attached? (Note 9) NO Date of disclosure 14 DECEMBER 2005 Contact name BARCLAYS CORPORATE SECRETARIAT Telephone number 020 7116 2913 If a connected EFM, name of offeree/offeror with which connected If a connected EFM, state nature of connection (Note 10) Notes The Notes on Form 8.3 can be viewed on the Takeover Panel's website at www.thetakeoverpanel.org.uk

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Barclays (BARC)
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