Rule 8.3 - SKYEPHARMA PLC

FORM 8.3
    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE
              (Rule 8.3 of the City Code on Takeovers and Mergers)


1.   KEY INFORMATION

Name of person dealing  (Note 1)        BARCLAYS PLC
Company dealt in                        SKYEPHARMA PLC
Class of relevant security to which     ORD GBP 0.10
the dealings being disclosed relate
(Note 2)
Date of dealing                         14 NOVEMBER 2005


2.   INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a)  Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                             Long                             Short

                              Number                (%)              Number                    (%)
(1) Relevant securities     21,649,558            (2.86%)         8,807,710                  (1.16%)

(2) Derivatives
(other than options)                                             10,813,938                  (1.43%)

(3) Options and
agreements to                 11,000              (0.00%)
purchase/sell

Total                      21,660,558             (2.86%)        19,621,648                  (2.59%)


(b)  Interests and short positions in relevant securities of the company, other
     than the class dealt in (Note 3)

Class of relevant security:                         Long                         Short

                                        Number                       Number
                                        (%)                          (%)
(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to
purchase/sell

Total


(c)  Rights to subscribe (Note 3)

Class of relevant security:             Details





3.   DEALINGS (Note 4)

(a)  Purchases and sales

Purchase/sale                     Number of securities            Price per unit (Note 5)

Purchase                          253,220                         0.4893
Purchase                          218,167                         0.4880
Purchase                          260,394                         0.4837
Purchase                          29,386                          0.5024
Sale                              8,964                           0.4839
Sale                              17,971                          0.4922
Sale                              29,040                          0.4978



(b)  Derivatives transactions (other than options)

Product name,      Long/short (Note 6)   Number of securities (Note 7)   Price per unit (Note 5)
e.g. CFD
CFD                Short                 253,220                         0.4893
CFD                Short                 218,167                         0.4880
CFD                Short                 260,394                         0.4837
CFD                Short                 29,386                          0.5024
CFD                Long                  8,964                           0.4839
CFD                Long                  17,971                          0.4922
CFD                Long                  29,040                          0.4978
CFD                Long                  301,083                         0.4848
CFD                Long                  359,367                         0.4834
CFD                Long                  94,694                          0.4848
CFD                Long                  113,020                         0.4834
CFD                Long                  386,056                         0.4848
CFD                Long                  460,786                         0.4834
CFD                Long                  218,167                         0.4880
CFD                Long                  260,394                         0.4834



(c)  Options transactions in respect of existing securities

(i)  Writing, selling, purchasing or varying

Product name,      Writing,       Number of         Exercise  Type, e.g.   Expiry    Option money
e.g. call option   selling,       securities to     price     American,    date      paid/received
                   purchasing,    which the option            European               per unit
                   varying etc.   relates (Note 7)            etc.                   (Note 5)



(ii) Exercising

Product name, e.g. call option    Number of securities            Exercise price per unit (Note 5)






(d)  Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)    Details                         Price per unit (if applicable)
                                                                  (Note 5)













4.   OTHER INFORMATIONS

Agreements, arrangements or understandings relating to options or derivatives


Full details of any agreement, arrangement or understanding between the person disclosing and any
other person relating to the voting rights of any relevant securities under any option referred to
on this form or relating to the voting rights or future acquisition or disposal of any relevant
securities to which any derivative referred to on this form is referenced.  If none, this should
be stated.





Is a Supplemental Form 8 attached? (Note 9)                 NO


Date of disclosure                                       15 NOVEMBER 2005
Contact name                                             BARCLAYS CORPORATE SECRETARIAT
Telephone number                                         020 7116 2913
If a connected EFM, name of offeree/offeror with which
connected
If a connected EFM, state nature of connection (Note
10)


Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk