Rule 8.3 - SKYEPHARMA PLC

FORM 8.3
    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE
              (Rule 8.3 of the City Code on Takeovers and Mergers)


1.   KEY INFORMATION

Name of person dealing  (Note 1)        BARCLAYS PLC
Company dealt in                        SKYEPHARMA PLC
Class of relevant security to which     GBP 0.10
the dealings being disclosed relate
(Note 2)
Date of dealing                         16 NOVEMBER 2005


2.   INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a)  Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                                    Long                         Short

                                        Number               (%)         Number             (%)

(1) Relevant securities              22,918,575            (3.03%)     8,841,557          (1.17%)

(2) Derivatives
(other than options)                                                   7,473,918          (0.99%)

(3) Options and agreements to
purchase/sell

Total                                22,918,575            (3.03%)    16,315,475          (2.16%)


(b)  Interests and short positions in relevant securities of the company, other
     than the class dealt in (Note 3)

Class of relevant security:                         Long                         Short

                                        Number                       Number
                                        (%)                          (%)
(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to
purchase/sell

Total


(c)  Rights to subscribe (Note 3)

Class of relevant security:             Details





3.   DEALINGS (Note 4)

(a)  Purchases and sales

Purchase/sale                     Number of securities            Price per unit (Note 5)

Purchase                          65,450                          0.5192
Purchase                          235,622                         0.5193
Purchase                          130,901                         0.5180
Purchase                          21,307                          0.5183
Purchase                          218,167                         0.4880
Purchase                          65,450                          0.5180
Purchase                          327,253                         0.5267
Sale                              32,706                          0.5231
Sale                              45,556                          0.5226
Sale                              85,295                          0.5182



(b)  Derivatives transactions (other than options)

Product name,      Long/short (Note 6)   Number of securities (Note 7)   Price per unit (Note 5)
e.g. CFD
CFD                Short                 65,450                          0.5192
CFD                Short                 235,622                         0.5193
CFD                Short                 130,901                         0.5180
CFD                Short                 21,307                          0.5183
CFD                Long                  32,706                          0.5231
CFD                Long                  45,556                          0.5226
CFD                Long                  85,295                          0.5182
CFD                Long                  596,142                         0.5189
CFD                Long                  187,496                         0.5189
CFD                Long                  764,389                         0.5189
CFD                Long                  431,973                         0.5189



(c)  Options transactions in respect of existing securities

(i)  Writing, selling, purchasing or varying

Product name,      Writing,       Number of         Exercise  Type, e.g.   Expiry    Option money
e.g. call option   selling,       securities to     price     American,    date      paid/received
                   purchasing,    which the option            European               per unit
                   varying etc.   relates (Note 7)            etc.                   (Note 5)



(ii) Exercising

Product name, e.g. call option    Number of securities            Exercise price per unit (Note 5)






(d)  Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)    Details                         Price per unit (if applicable)
                                                                  (Note 5)













4.   OTHER INFORMATIONS

Agreements, arrangements or understandings relating to options or derivatives


Full details of any agreement, arrangement or understanding between the person disclosing and any
other person relating to the voting rights of any relevant securities under any option referred to
on this form or relating to the voting rights or future acquisition or disposal of any relevant
securities to which any derivative referred to on this form is referenced.  If none, this should
be stated.





Is a Supplemental Form 8 attached? (Note 9)                 NO


Date of disclosure                                       17 NOVEMBER 2005
Contact name                                             BARCLAYS CORPORATE SECRETARIAT
Telephone number                                         020 7116 2913
If a connected EFM, name of offeree/offeror with which
connected
If a connected EFM, state nature of connection (Note
10)


Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk