Rule 8.3 - SKYEPHARMA PLC

FORM 8.3

    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE
              (Rule 8.3 of the City Code on Takeovers and Mergers)


1.   KEY INFORMATION

Name of person dealing  (Note 1)           BARCLAYS PLC
Company dealt in                           SKYEPHARMA PLC
Class of relevant security to which the    GBP 0.10
dealings being disclosed relate (Note 2)
Date of dealing                            17 NOVEMBER 2005


2.   INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a)  Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                                     Long                            Short

                                           Number               (%)         Number               (%)

(1) Relevant securities                    22,810,882       (3.02%)         8,323,458        (1.10%)

(2) Derivatives (other than options)                                        6,579,843        (0.87%)

(3) Options and agreements to
purchase/sell

Total                                      22,810,882       (3.02%)        14,903,301        (1.97%)


(b)  Interests and short positions in relevant securities of the company, other
     than the class dealt in (Note 3)

Class of relevant security:                           Long                            Short

                                           Number                (%)         Number               (%)

(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to
purchase/sell

Total


(c)  Rights to subscribe (Note 3)

Class of relevant security:                Details



3.   DEALINGS (Note 4)

(a)  Purchases and sales

Purchase/sale                       Number of securities              Price per unit (Note 5)

Purchase                            26,250                            0.5228
Purchase                            87,267                            0.5130
Purchase                            91,630                            0.5092
Purchase                            109,085                           0.5105
Sale                                65,450                            0.5180
Sale                                327,253                           0.5267
Sale                                29,222                            0.5109


(b)  Derivatives transactions (other than options)

Product name,       Long/short (Note 6)     Number of securities (Note 7)    Price per unit (Note 5)
e.g. CFD
CFD                 Short                   26,250                           0.5228
CFD                 Short                   87,267                           0.5130
CFD                 Short                   91,630                           0.5092
CFD                 Short                   109,085                          0.5105
CFD                 Long                    29,222                           0.5109
CFD                 Long                    343,163                          0.5109
CFD                 Long                    107,929                          0.5109
CFD                 Long                    440,011                          0.5109
CFD                 Long                    287,982                          0.5108


(c)  Options transactions in respect of existing securities

(i)  Writing, selling, purchasing or varying

Product name,       Writing,        Number of           Exercise  Type, e.g.    Expiry    Option money
e.g. call option    selling,        securities to       price     American,     date      paid/received
                    purchasing,     which the option              European                per unit (Note
                    varying etc.    relates (Note 7)              etc.                    5)


(ii) Exercising

Product name, e.g. call option      Number of securities              Exercise price per unit (Note 5)


(d)  Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)      Details                           Price per unit (if applicable)
                                                                      (Note 5)


4.   OTHER INFORMATIONS

Agreements, arrangements or understandings relating to options or derivatives


Full details of any agreement, arrangement or understanding between the person disclosing and any other
person relating to the voting rights of any relevant securities under any option referred to on this
form or relating to the voting rights or future acquisition or disposal of any relevant securities to
which any derivative referred to on this form is referenced.  If none, this should be stated.





Is a Supplemental Form 8 attached? (Note 9)                 NO


Date of disclosure                                           18 NOVEMBER 2005
Contact name                                                 BARCLAYS CORPORATE SECRETARIAT
Telephone number                                             020 7116 2913
If a connected EFM, name of offeree/offeror with which
connected
If a connected EFM, state nature of connection (Note 10)


Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk