Rule 8.3 - SKYEPHARMA PLC

FORM 8.3
    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE
              (Rule 8.3 of the City Code on Takeovers and Mergers)


1.   KEY INFORMATION

Name of person dealing  (Note 1)           BARCLAYS PLC
Company dealt in                           SKYEPHARMA PLC
Class of relevant security to which the    GBP 0.10
dealings being disclosed relate (Note 2)
Date of dealing                            23 NOVEMBER 2005


2.   INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a)  Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                            Long                                   Short

                                      Number          (%)                    Number         (%)

(1) Relevant securities               16,611,385  (2.20%)                    1,221,512  (0.16%)
(2) Derivatives (other                1,358,121   (0.18%)                    2,129,538  (0.28%)
than options)
(3) Options and agreements            0           (0.00%)                    0          (0.00%)
to purchase/sell
Total                                 17,969,506  (2.38%)                    3,351,050  (0.44%)

(b)  Interests and short positions in relevant securities of the company, other
     than the class dealt in (Note 3)

Class of relevant security:                           Long                            Short

                                          Number            (%)             Number              (%)

(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to
purchase/sell

Total


(c)  Rights to subscribe (Note 3)

Class of relevant security:               Details


3.   DEALINGS (Note 4)

(a)  Purchases and sales

Purchase/sale              Number of Securities                     Price per unit (GBP)
Sale                       89,550                                   0.5634
Sale                       17,747                                   0.5799
Sale                       40,000                                   0.5631
Purchase                   429,552                                  0.5630
Purchase                   67,075                                   0.5775

(b)  Derivatives transactions (other than options)

Product name, e.g. Long/Short (Note 6)      Number of Securities (Note 7)        Price Per Unit (GBP)
CFD
CFD                Long                     89,550                                0.5634
CFD                Long                     17,747                                0.5799
CFD                Long                     40,000                                0.5631
CFD                Short                    429,552                               0.5630
CFD                Short                    67,075                                0.5775
CFD                Long                     604,775                               0.5630
CFD                Long                     190,214                               0.5630
CFD                Long                     775,459                               0.5630
CFD                Long                     429,552                               0.5630


(c)  Options transactions in respect of existing securities

(i)  Writing, selling, purchasing or varying

Product name,      Writing,        Number of           Exercise  Type, e.g.    Expiry     Option money
e.g. call option   selling,        securities to       price     American,     date       paid/received
                   purchasing,     which the option              European                 per unit (Note
                   varying etc.    relates (Note 7)              etc.                     5)



(ii) Exercising

Product name, e.g. call option     Number of securities              Exercise price per unit (Note 5)




(d)  Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)     Details                           Price per unit (if applicable)
                                                                     (Note 5)



4.   OTHER INFORMATIONS

Agreements, arrangements or understandings relating to options or derivatives


Full details of any agreement, arrangement or understanding between the person disclosing and any other
person relating to the voting rights of any relevant securities under any option referred to on this
form or relating to the voting rights or future acquisition or disposal of any relevant securities to
which any derivative referred to on this form is referenced.  If none, this should be stated.



Is a Supplemental Form 8 attached? (Note 9)                 NO


Date of disclosure                                          24 NOVEMBER 2005
Contact name                                                BARCLAYS CORPORATE SECRETARIAT
Telephone number                                            020 7116 2913
If a connected EFM, name of offeree/offeror with which
connected
If a connected EFM, state nature of connection (Note 10)


Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk