Rule 8.3 - SKYEPHARMA PLC

FORM 8.3
    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE
              (Rule 8.3 of the City Code on Takeovers and Mergers)


1.   KEY INFORMATION

Name of person dealing  (Note 1)        BARCLAYS PLC
Company dealt in                        SKYEPHARMA PLC
Class of relevant security to which     GBP 0.10
the dealings being disclosed relate
(Note 2)
Date of dealing                         25 NOVEMBER 2005


2.   INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a)  Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                         Long                                 Short

                                   Number       (%)                      Number       (%)

(1) Relevant securities          17,362,544  (2.30%)                     749,458    (0.10%)
(2) Derivatives (other             752,057   (0.10%)                     261,227    (0.03%)
than options)
(3) Options and                       0      (0.00%)                        0       (0.00%)
agreements to
purchase/sell
Total                            18,114,601  (2.40%)                    1,010,685   (0.13%)

(b)  Interests and short positions in relevant securities of the company, other
     than the class dealt in (Note 3)

Class of relevant security:                        Long                          Short

                                        Number                       Number
                                        (%)                          (%)
(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to
purchase/sell

Total


(c)  Rights to subscribe (Note 3)

Class of relevant security:             Details





3.   DEALINGS (Note 4)

(a)  Purchases and sales


Purchase/sale            Number of Securities                   Price per unit (GBP)
Purchase                 465,909                                0.4750
Sale                     50,000                                 0.4735
Sale                     50,000                                 0.4744

 (b) Derivatives transactions (other than options)

Product name,     Long/Short (Note 6)    Number of Securities (Note 7)      Price Per Unit (GBP)
e.g. CFD
CFD               Long                                              50,000                  0.4735
CFD               Long                                              50,000                  0.4744
CFD               Short                                            465,909                  0.4750
CFD               Short                                            100,000

(c)  Options transactions in respect of existing securities

(i)  Writing, selling, purchasing or varying

Product name,     Writing,       Number of          Exercise  Type, e.g.   Expiry   Option money
e.g. call option  selling,       securities to      price     American,    date     paid/received
                  purchasing,    which the option             European              per unit
                  varying etc.   relates (Note 7)             etc.                  (Note 5)



(ii) Exercising

Product name, e.g. call option   Number of securities            Exercise price per unit (Note 5)






(d)  Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)   Details                         Price per unit (if applicable)
                                                                 (Note 5)




4.   OTHER INFORMATIONS

Agreements, arrangements or understandings relating to options or derivatives


Full details of any agreement, arrangement or understanding between the person disclosing and any
other person relating to the voting rights of any relevant securities under any option referred to
on this form or relating to the voting rights or future acquisition or disposal of any relevant
securities to which any derivative referred to on this form is referenced.  If none, this should
be stated.





Is a Supplemental Form 8 attached? (Note 9)                 NO


Date of disclosure                                      28 NOVEMBER 2005
Contact name                                            BARCLAYS CORPORATE SECRETARIAT
Telephone number                                        020 7116 2913
If a connected EFM, name of offeree/offeror with which
connected
If a connected EFM, state nature of connection (Note
10)


Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk