Rule 8.3 - SKYEPHARMA PLC

FORM 8.3 DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE (Rule 8.3 of the City Code on Takeovers and Mergers) 1. KEY INFORMATION Name of person dealing (Note 1) BARCLAYS PLC Company dealt in SKYEPHARMA PLC Class of relevant security to which GBP 0.10 the dealings being disclosed relate (Note 2) Date of dealing 25 NOVEMBER 2005 2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE (a) Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3) Long Short Number (%) Number (%) (1) Relevant securities 17,362,544 (2.30%) 749,458 (0.10%) (2) Derivatives (other 752,057 (0.10%) 261,227 (0.03%) than options) (3) Options and 0 (0.00%) 0 (0.00%) agreements to purchase/sell Total 18,114,601 (2.40%) 1,010,685 (0.13%) (b) Interests and short positions in relevant securities of the company, other than the class dealt in (Note 3) Class of relevant security: Long Short Number Number (%) (%) (1) Relevant securities (2) Derivatives (other than options) (3) Options and agreements to purchase/sell Total (c) Rights to subscribe (Note 3) Class of relevant security: Details 3. DEALINGS (Note 4) (a) Purchases and sales Purchase/sale Number of Securities Price per unit (GBP) Purchase 465,909 0.4750 Sale 50,000 0.4735 Sale 50,000 0.4744 (b) Derivatives transactions (other than options) Product name, Long/Short (Note 6) Number of Securities (Note 7) Price Per Unit (GBP) e.g. CFD CFD Long 50,000 0.4735 CFD Long 50,000 0.4744 CFD Short 465,909 0.4750 CFD Short 100,000 (c) Options transactions in respect of existing securities (i) Writing, selling, purchasing or varying Product name, Writing, Number of Exercise Type, e.g. Expiry Option money e.g. call option selling, securities to price American, date paid/received purchasing, which the option European per unit varying etc. relates (Note 7) etc. (Note 5) (ii) Exercising Product name, e.g. call option Number of securities Exercise price per unit (Note 5) (d) Other dealings (including new securities) (Note 4) Nature of transaction (Note 8) Details Price per unit (if applicable) (Note 5) 4. OTHER INFORMATIONS Agreements, arrangements or understandings relating to options or derivatives Full details of any agreement, arrangement or understanding between the person disclosing and any other person relating to the voting rights of any relevant securities under any option referred to on this form or relating to the voting rights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form is referenced. If none, this should be stated. Is a Supplemental Form 8 attached? (Note 9) NO Date of disclosure 28 NOVEMBER 2005 Contact name BARCLAYS CORPORATE SECRETARIAT Telephone number 020 7116 2913 If a connected EFM, name of offeree/offeror with which connected If a connected EFM, state nature of connection (Note 10) Notes The Notes on Form 8.3 can be viewed on the Takeover Panel's website at www.thetakeoverpanel.org.uk

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