Rule 8.3 - SYGEN INTERNATIONAL

FORM 8.3

DEALINGS BY PERSONS WHO OWN OR CONTROL 1% OR MORE OF ANY CLASS OF RELEVANT SECURITY
(Rule 8.3 of The City Code on Takeovers and Mergers)

Name of purchaser/vendor *                               BARCLAYS PLC
Company dealt in                                         SYGEN INTERNATIONAL
Relevant security dealt in                               ORD GBP 0.10
If a connected EFM, name of offeree/offeror with
which connected
If a connected EFM, nature of connection #
Date of dealing                                          12 OCTOBER 2005

DEALINGS †

Amount bought                      Price per unit (currency must be stated)
17,340                             0.5300

Amount sold                        Price per unit (currency must be stated)


Resultant total amount and percentage of the
same relevant security owned or controlled   5,969,680 (2.02%)

IS A SUPPLEMENTAL FORM 8 (DERIVATIVE)/FORM 8 (OPTION) ATTACHED? YES

Date of disclosure  13 OCTOBER 2005
Contact name        BARCLAYS CORPORATE SECRETARIAT
Telephone number    0207 116 2913

* Specify the owner or controller in addition to the person dealing. The naming of nominees or vehicle companies is
insufficient.

In the case of disclosure of dealings by fund managers on behalf of discretionary clients, the clients need not be
named.

# See the definition of "connected fund managers and principal traders" in the Definitions Section of the Code.

† If disclosing dealings/holdings in derivatives or options, please attach Supplemental Form 8 (Derivative) or
Supplemental

Form 8 (Option), as appropriate.

For details of the Code's dealing disclosure requirements, see Rule 8 and its Notes which can be viewed on the Takeover
Panel's website at www.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (DERIVATIVE)

DEALINGS/HOLDINGS IN DERIVATIVES
(This form should be attached to Form 8.1, Form 8.1(b)(ii), Form 8.2 or Form 8.3, as appropriate)

Description of all derivative products       CFD - A purchaser of a CFD will realise
disclosed on this form                       a gain if the price of the underlying security
                                             goes up. A seller of a CFD will realise a gain
                                             if the price of the underlying security goes down.
                                             The CFD contracts are open ended and there is no
                                             rollover into new contracts.


Full details of any agreement, arrangement   None
or understanding between the person
disclosing and any other person relating
to the voting rights or future acquisition
or disposal of any relevant securities to
which any derivative referred to on this
form is referenced. If none, this should
be stated.


WRITING/ENTERING INTO A DERIVATIVE

Product name   Transaction    Writing/        Number of        Reference price   Maturity date
eg long CFD    date           entering into   securities       (currency
                              (indicate as    to which the     must be stated)
                              applicable)     derivative
                                              is referenced


CLOSING OUT A DERIVATIVE

Product name   Transaction    Number of        Reference price   Closing out price
eg long CFD    date           securities       (currency         (currency must be
                              to which the     must be stated)   stated)
                              derivative
                              is referenced


DETAILS OF OPEN DERIVATIVES (excluding any transaction set out above)

Product name   Transaction    Written/        Number of          Reference price   Maturity date
eg long CFD    date           entered into    securities         (currency
                              (indicate as    to which the       must be stated)
                              applicable)     derivative
                                              is referenced
Short CFD      03/06/2004     Entered into    330,489            0.4595
Short CFD      07/06/2004     Entered into    441,039            0.4595
Short CFD      17/06/2004     Entered into    100,000            0.4400
Short CFD      21/06/2004     Entered into    394,547            0.3996
Short CFD      23/06/2004     Entered into    206,900            0.3896
Short CFD      07/07/2004     Entered into    50,000             0.3600
Short CFD      09/07/2004     Entered into    100,000            0.3297
Short CFD      19/07/2004     Entered into    63,870             0.3425
Short CFD      26/07/2004     Entered into    150,933            0.2997
Short CFD      30/07/2004     Entered into    59,530             0.3150
Short CFD      10/08/2004     Entered into    100,000            0.3350
Short CFD      17/11/2004     Entered into    60,759             0.3921
Short CFD      24/11/2004     Entered into    156,209            0.3900
Long CFD       23/05/2005     Entered into    290,000            0.3754
Long CFD       09/06/2005     Entered into    174,650            0.3904
Long CFD       19/07/2005     Entered into    11,705             0.3850
Short CFD      23/09/2005     Entered into    10,500             0.5025