Holding(s) in Company

Finsbury Life Sciences Inv Tst PLC
18 September 2002

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1) Name of company

Finsbury Life Sciences Investment Trust PLC

2) Name of shareholder having a major interest

HSBC Investment Bank plc

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18

As above

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

James Capel (Nominees) Limited                    1,898,203

James Capel (Nominees) Limited - CHTY               1,367,600

James Capel (Nominees) Limited - RA                     12,000

James Capel (Nominees) Limited - Channel Islands      138,000

Unknown                                         174,990

                                             3,590,793

5) Number of shares/amount of stock acquired

not stated

6) Percentage of issued class

n/a

7) Number of shares/amount of stock disposed

n/a

8) Percentage of issued class

n/a

9) Class of security

Ordinary shares of 25p each

10) Date of transaction

13 September 2002

11) Date company informed

17 September 2002

12) Total holding following this notification

3,590,793


13) Total percentage holding of issued class following this notification

11.9%

14) Any additional information

HSBC Investment Bank Holdings plc as HSBC Invesment Bank plc's parent and HSBC
Holdings plc, the ultimate parent company, were also interested, by virtue of
s.203 of the Act in all of the above mentioned shares.

15) Name of contact and telephone number for queries

Faith Pengelly

Close Finsbury Asset Management Limited

Secretary

Tel: [phone]

18 September 2002





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