Holding(s) in Company

Finsbury Life Sciences Inv Tst PLC
13 April 2005

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company


Finsbury Life Sciences Investment Trust PLC



2. Name of shareholder having a major interest


Samuel D Isaly



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18


As in 2 above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


As in 2 above



5. Number of shares / amount of stock acquired


965,964



6. Percentage of issued class *


3.49%



7. Number of shares / amount of stock disposed


N/A



8. Percentage of issued class


-



9. Class of security


Ordinary shares of 25p each



10. Date of transaction


8 April 2005






11. Date company informed


 13 April 2005



12. Total holding following this notification


965,964



13. Total percentage holding of issued class following this notification*


3.49%



14. Any additional information


* Based on the issued share capital of 27,675,000 Ordinary shares, following a 
buy-back of shares for cancellation by the Company of 1,975,000 on 7 April 2005 
and 450,000 on 8 April 2005.



15. Name of contact and telephone number for queries


Tracey Lago - 020 7426 6219



16. Name and signature of authorised company official responsible for making
this notification


Tracey Lago

For and on behalf of Close Finsbury Asset Management Limited



Date of notification


13 April 2005



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for loss of business or loss of profits) arising in contract, tort or otherwise
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