Director/PDMR Shareholding

Cambridge Antibody Tech Group PLC
25 November 2005


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DIANE MELLETT



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



GREENWOOD NOMINEES LIMITED



8 State the nature of the transaction



PURCHASE OF SHARES FOLLOWING EXERCISE OF OPTION



9. Number of shares, debentures or financial instruments relating to shares
acquired

7597


10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)


0.014%



11. Number of shares, debentures or financial instruments relating to shares
disposed

NIL


12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)


NIL



13. Price per share or value of transaction



£2.42



14. Date and place of transaction



25 NOVEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



22,659

0.043%



16. Date issuer informed of transaction



25 NOVEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



....................................



18. Period during which or date on which it can be exercised



....................................



19. Total amount paid (if any) for grant of the option



....................................



20. Description of shares or debentures involved (class and number)



....................................

....................................



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



....................................



22. Total number of shares or debentures over which options held following
notification



....................................



23. Any additional information



THE OPTION WHICH WAS EXERCISED WAS DUE TO IRREVOCABLY LAPSE ON 27 NOVEMBER 2005
IF IT HAD NOT BEEN EXERCISED PRIOR TO THAT DATE.



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898 589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



25 NOVEMBER 2005

END





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