Director/PDMR Shareholding

Cambridge Antibody Tech Group PLC
05 December 2005

NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.




Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JOHN ASTON



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



338



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



60,300

0.114%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



25,742 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

143,568 OF WHICH:

44,180 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

82,507 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN

16,881 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END




NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



NIGEL BURNS



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



294



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



3,554

0.0067%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



10,095 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

83,773 OF WHICH:

54,723 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

29,050 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PETER CHAMBRE



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



352



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



26,442

0.050%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



52,511 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

381,072 OF WHICH:

191,969 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

145,021 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN

44,082 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



ALEXANDER DUNCAN



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



323



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



14,439

0.027%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



11,441 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

64,803 OF WHICH:

31,776 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

29,640 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN

3,387 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



JUSTIN HOSKINS



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



294



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



2,460

0.0046%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



2 DECEMBER 2008 TO 1 DECEMBER 2015 SUBJECT TO PERFORMANCE CONDITION



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



3,930 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



£6.84 PENCE PER SHARE SUBJECT TO PERFORMANCE CONDITION



22. Total number of shares or debentures over which options held following
notification

11,764 OPTIONS UNDER COMPANY SHARE OPTION PLAN



23. Any additional information



NONE

24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



LYNN LESTER



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



323



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



2,424

0.0046%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



7,704 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

24,906 OF WHICH:

12,361 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

10,421 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN

2,124 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



RICHARD MASON



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



308



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



3,262

0.0062%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



(1) 2 DECEMBER 2005

(2) 2 DECEMBER 2005



18. Period during which or date on which it can be exercised



(1) 30 DECEMBER 2008 TO 29 DECEMBER 2011

(2) 2 DECEMBER 2008 TO 1 DECEMBER 2015



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



(1) 3,036 ORDINARY 10 PENCE SHARES

(2) 9,137 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



(1) 10 PENCE PER SHARE SUBJECT TO AWARD

(2) £6.84 PER SHARE SUBJECT TO PERFORMANCE CONDITION



22. Total number of shares or debentures over which options held following
notification

45,138 OF WHICH:

39,958 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

5,180 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



DIANE MELLETT



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



308



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



18,271

0.035%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



19,207 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

118,423 OF WHICH:

63,304 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

51,108 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN

4,011 ARE MATCHING SHARES UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).


(1)   An issuer making a notification in respect of a transaction relating to
      the shares or debentures of the issuer should complete boxes 1 to 16, 23
      and 24.
(2)   An issuer making a notification in respect of a derivative relating the
      shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23 and
      24.
(3)   An issuer making a notification in respect of options granted to a
      director/person discharging managerial responsibilities should complete
      boxes 1 to 3 and 17 to 24.
(4)   An issuer making a notification in respect of a financial instrument
      relating to the shares of the issuer (other than a debenture) should
      complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes should in block capital letters.



1. Name of the issuer



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or

(ii) DR 3.1.4(R)(1)(b) a disclosure made in accordance with section 324 (as
extended by section 328) of the Companies Act 1985; or

(iii) both (i) and (ii)



(ii)



3. Name of person discharging managerial responsibilities/director



PATRICK ROUND



4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person



AS IN 3 ABOVE



5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest



AS IN 3 ABOVE



6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares



ORDINARY 10 PENCE SHARES



7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them



COMPUTERSHARE TRUSTEES LIMITED



8 State the nature of the transaction



ALLOCATION OF FREESHARES UNDER INLAND REVENUE APPROVED SHARE INCENTIVE PLAN



9. Number of shares, debentures or financial instruments relating to shares
acquired



294



10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)



0.0006%



11. Number of shares, debentures or financial instruments relating to shares
disposed



NIL



12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)



NIL



13. Price per share or value of transaction



£6.80



14. Date and place of transaction



1 DECEMBER 2005

LONDON



15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)



294

0.0006%



16. Date issuer informed of transaction



1 DECEMBER 2005



If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes



17 Date of grant



2 DECEMBER 2005



18. Period during which or date on which it can be exercised



30 DECEMBER 2008 TO 29 DECEMBER 2011



19. Total amount paid (if any) for grant of the option



NIL



20. Description of shares or debentures involved (class and number)



11,557 ORDINARY 10 PENCE SHARES



21. Exercise price (if fixed at time of grant) or indication that price is to be
fixed at the time of exercise



10 PENCE PER SHARE SUBJECT TO AWARD



22. Total number of shares or debentures over which options held following
notification

55,466 OF WHICH:

5,725 ARE OPTIONS UNDER COMPANY SHARE OPTION PLAN

49,741 ARE RESTRICTED SHARE AWARDS UNDER EXECUTIVE INCENTIVE PLAN



23. Any additional information



AWARDS GRANTED UNDER THE EXECUTIVE INCENTIVE PLAN ARE SUBJECT TO PERFORMANCE
CONDITIONS



24. Name of contact and telephone number for queries



JUSTIN HOSKINS

01223 898589



Name and signature of duly authorised officer of issuer responsible for making
notification



JUSTIN HOSKINS

COMPANY SECRETARY



Date of notification



2 DECEMBER 2005

END

















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