Director S/holding-Replacemnt

Cambridge Antibody Tech Group PLC
4 December 2000



The issuer has made the following amendment to the 'Director Shareholding -
Amendmt' announcement released 1 December 2000 at 13:24 under RNS No 0981V.

The dealings of the following directors should read:-

Kevin Johnson:-
Box 4 changed to 'as in 2'
Boxes 17-21 should be blank.

David Chiswell:-
Box 4 should be changed to 'Linda Chiswell'


All other details remain unchanged.

The full corrected version is shown below.



Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
Kevin Johnson

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:


4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
As in 2

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Exercise and sale of 59,242 options granted under Company Share Option Scheme.

7   Number of shares/amount of stock acquired:
59,242

8   Percentage of issued class:
0.17%

9   Number of shares/amount of stock disposed:
59,242

10  Percentage of issued class:
0.17%

11  Class of security:
10p ordinary shares

12  Price per share:
£41.00

13  Date of transaction:
28 September 2000

14  Date company informed:
28 September 2000

15  Total holding following this notification:
63,627 (with spouse)

16  Total percentage holding of issued class following this notification:
0.18%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
David Glover

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:


4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
As in 2 

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Exercise of 45,000 options and sale of 43,000 options granted under Company
Share Option Scheme.

7   Number of shares/amount of stock acquired:
45,000 

8   Percentage of issued class:
0.13%

9   Number of shares/amount of stock disposed:
43,000

10  Percentage of issued class:
0.12%

11  Class of security:
10p ordinary shares

12  Price per share:
£41.00

13  Date of transaction:
28 September 2000

14  Date company informed:
28 September 2000

15  Total holding following this notification:
9,327

16  Total percentage holding of issued class following this notification:
0.03%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
Peter Garland

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
As in 2

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):


6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Sale of shares

7   Number of shares/amount of stock acquired:
Nil

8   Percentage of issued class:


9   Number of shares/amount of stock disposed:
32,500

10  Percentage of issued class:
0.09%

11  Class of security:
10p ordinary shares

12  Price per share:
£41.00

13  Date of transaction:
28 September 2000

14  Date company informed:
28 September 2000

15  Total holding following this notification:
49,500 (with spouse)

16  Total percentage holding of issued class following this notification:
0.14%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
David Chiswell

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
Spouse

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
Linda Chiswell

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
Spouse

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Sale of shares

7   Number of shares/amount of stock acquired:
Nil

8   Percentage of issued class:


9   Number of shares/amount of stock disposed:
150,000

10  Percentage of issued class:
0.43%

11  Class of security:
10p ordinary shares

12  Price per share:
£41.00

13  Date of transaction:
28 September 2000

14  Date company informed:
28 September 2000

15  Total holding following this notification:
476,127

16  Total percentage holding of issued class following this notification:
1.36%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
Cambridge Antibody Technology

2   Name of director:
Sir Aaron Klug

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
As in 2 and spouse

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
Sir Aaron Klug (15,649)and Lady Liebe Klug (12,408)

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
As in 2 and Spouse

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
Sale of shares

7   Number of shares/amount of stock acquired:
Nil

8   Percentage of issued class:


9   Number of shares/amount of stock disposed:
10,000 

10  Percentage of issued class:
0.03%

11  Class of security:
Ordinary 10p shares

12  Price per share:
£41.00

13  Date of transaction:
28 September 2000

14  Date company informed:
28 September 2000

15  Total holding following this notification:
28,057

16  Total percentage holding of issued class following this notification:
0.08%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:


18  Period during which or date on which exercisable:


19  Total amount paid (if any) for grant of the option:


20  Description of shares or debentures involved: class, number:


21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:


22  Total number of shares or debentures over which options held following
this notification:


23  Contact name for queries:
Diane Mellett

24  Contact telephone number:
01763 263233

25  Name of company official responsible for making notification:
Company Secretary





Additional Information: